Int J Med Sci 2022; 19(4):762-768. doi:10.7150/ijms.69868 This issue
1. School of Dentistry, China Medical University, Taichung 40402, Taiwan.
2. Department of Dentistry, China Medical University Hospital, Taichung 40447, Taiwan.
3. School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
4. Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
5. School of Medicine, China Medical University, Taichung 40402, Taiwan.
6. Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 404332, Taiwan.
7. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
8. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
9. Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan.
10. Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan.
11. Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan.
Oral cancer is the eighth greatest generally diagnosed cancer amongst males worldwide and the fourth most generally malignancy amongst Taiwanese males. The pro-inflammatory adipocytokine visfatin promotes tumor growth. Elevated plasma visfatin levels have been identified in patients with oral squamous cell carcinoma (OSCC), although the biological mechanisms underlying the involvement of visfatin in the pathogenesis of OSCC are not well understood. Moreover, no information is available regarding associations between visfatin polymorphisms and carcinogenic lifestyle factors with OSCC. This study, therefore, investigated the effects of four visfatin gene polymorphisms (rs11977021, rs61330082, rs2110385, and rs4730153) and carcinogenic lifestyle factors (betel nut chewing, alcohol consumption and cigarette smoking) on the risk of developing OSCC in 1,275 Taiwanese males with OSCC, and 1,195 healthy males (controls). We also examined the associations between these visfatin genotypes and OSCC histopathological prognostic factors (pathological stage, tumor status, lymph node status, and metastasis). We found that compared with subjects with the CC genotype of SNP rs11977021, those with the CT+TT genotype were less likely to progress OSCC. In addition, an association was found between the rs4730153 variant and lymph node metastasis in the OSCC cohort.
Keywords: genetic polymorphisms, oral squamous cell carcinoma, visfatin