Int J Med Sci 2021; 18(16):3644-3651. doi:10.7150/ijms.46834

Review

The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells

Wangxiao Bao, Yajun Lin, Zuobing Chen

Department of Rehabilitation Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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Citation:
Bao W, Lin Y, Chen Z. The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells. Int J Med Sci 2021; 18(16):3644-3651. doi:10.7150/ijms.46834. Available from https://www.medsci.org/v18p3644.htm

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Abstract

Graphic abstract

Emerging evidence suggests that immune-inflammatory processes are key elements in the physiopathological events associated with traumatic brain injury (TBI). TBI is followed by T-cell-specific immunological changes involving several subsets of T-helper cells and the cytokines they produce; these processes can have opposite effects depending on the disease course and cytokine concentrations. Efforts are underway to identify the T-helper cells and cytokine profiles associated with prognosis. These predictors may eventually serve as effective treatment targets to decrease morbidity and mortality and to improve the management of TBI patients. Here, we review the immunological response to TBI, the possible molecular mechanisms of this response, and therapeutic strategies to address it.

Keywords: traumatic brain injury, cytokines, T-helper cell