Int J Med Sci 2021; 18(11):2457-2465. doi:10.7150/ijms.58516

Research Paper

The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics

Pei-Ju Wu1,2,3#, Chun-Hao Wang4#, Ming-Hong Hsieh2,5, Chung-Yuan Lee6,7, Po-Hui Wang1,2,3, Chiao-Wen Lin8, Shun-Fa Yang1,9✉, Maw-Sheng Lee1,2,3✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
3. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
4. Department of Medicine, National Taiwan University, Taipei, Taiwan.
5. Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
6. Department of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
7. Department of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan.
8. Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
#Equal contribution as first authors.

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Citation:
Wu PJ, Wang CH, Hsieh MH, Lee CY, Wang PH, Lin CW, Yang SF, Lee MS. The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics. Int J Med Sci 2021; 18(11):2457-2465. doi:10.7150/ijms.58516. Available from https://www.medsci.org/v18p2457.htm

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Abstract

The aims of this study were to explore the involvement of Aurora kinase A (AURKA) gene single nucleotide polymorphisms (SNPs) in uterine cervical cancer that has not yet been investigated. One hundred and six patients with cervical invasive cancer and 94 patients with precancerous lesions, and 302 Taiwanese female individuals were included. AURKA SNPs rs2273535, rs6024836, rs2064863 and rs1047972 were analyzed for genotypic distributions using real-time polymerase chain reaction. There were no statistically significant differences in the genetic frequencies of AURKA SNPs among patients with invasive cancer and those with precancerous lesions of uterine cervix and control women. There were no associations among AURKA SNPs and clinicopathologcal variables and recurrence and survival events. However, in a multivariate analysis, cervical cancer patients with adenocarcinoma (HR: 3.18, 95% CI: 1.23-8.23; p=0.017) and larger tumor (HR: 5.61, 95% CI: 2.10-14.95; p=0.001) had poorer recurrence-free survival. In conclusion, tumor size and pelvic lymph node status rather than AURKA SNPs were the most obvious independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.

Keywords: Aurora kinase A, single nucleotide polymorphisms, uterine cervical cancer, pelvic lymph node metastasis