Int J Med Sci 2021; 18(9):2042-2050. doi:10.7150/ijms.55496 This issue Cite

Research Paper

Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study

Natalia Mikhailichenko1,2, Yu-Hsun Wang3, James Cheng-Chung Wei1,4✉, Te-Jen Lai1,5✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
2. NEVRON International Medical Center, Vladivostok, 690078, Russia; nevron.vl@gmail.com.
3. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
4. Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.
5. Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.

Citation:
Mikhailichenko N, Wang YH, Wei JCC, Lai TJ. Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study. Int J Med Sci 2021; 18(9):2042-2050. doi:10.7150/ijms.55496. https://www.medsci.org/v18p2042.htm
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Abstract

Graphic abstract

Introduction: The interaction between hyperuricemia and the cognitive system is still under debate, with studies presenting somewhat conflicting results.

Objectives: This study aimed to investigate the risk of dementia in patients with gout who are administered anti-inflammatory drug treatment.

Methods: Gouty arthritis patients aged 50 years and older, who received at least one of the background therapy drugs (colchicine, corticosteroids, or nonsteroidal anti-inflammatory drugs for 6 months), were divided into the following groups and compared: patients who had dementia over a period of 5 years (n = 2,292) and matched patients without dementia (n = 2,292).

Results: We found that the most significant risk factors for dementia were stroke (OR, 2.66; 95% C.I., 2.33-3.03; AOR, 2.39; 95% C.I., 2.08-2.75) and depression (OR, 3.72; 95% C.I., 3.01-4.6; AOR, 3.25; 95% C.I., 2.60-4.05). The results of anti-gout drug administration, which impacted the dementia risk among patients of all ages (but especially in 50-64-year-old patients), demonstrated a higher risk ratio after 90 days of corticosteroid use (OR, 3.39; 95% C.I., 1.15-9.99), which was further increased after 180 days (OR, 3.61; 95% C.I., 1.31-9.94). We revealed that female patients experienced a significant increase in dementia risk after 90 days of corticosteroid administration, whereas male patients experienced a significant increase only after 180 days (OR, 1.52; 95% C.I., 1.06-2.17).

Conclusion: We had identified that > 90-day corticosteroid administration is a significant dementia risk factor in both female and male patients of all ages, especially in the 50-60-year-old group.

Keywords: anti-inflammatory drugs, dementia, gout, old age.


Citation styles

APA
Mikhailichenko, N., Wang, Y.H., Wei, J.C.C., Lai, T.J. (2021). Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study. International Journal of Medical Sciences, 18(9), 2042-2050. https://doi.org/10.7150/ijms.55496.

ACS
Mikhailichenko, N.; Wang, Y.H.; Wei, J.C.C.; Lai, T.J. Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study. Int. J. Med. Sci. 2021, 18 (9), 2042-2050. DOI: 10.7150/ijms.55496.

NLM
Mikhailichenko N, Wang YH, Wei JCC, Lai TJ. Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study. Int J Med Sci 2021; 18(9):2042-2050. doi:10.7150/ijms.55496. https://www.medsci.org/v18p2042.htm

CSE
Mikhailichenko N, Wang YH, Wei JCC, Lai TJ. 2021. Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study. Int J Med Sci. 18(9):2042-2050.

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