Int J Med Sci 2020; 17(18):2941-2946. doi:10.7150/ijms.49297 This issue

Research Paper

mu-Opioid Receptor Polymorphisms and Breast Cancer Recurrence in Adult Korean Women Undergoing Breast Cancer Surgery: A Retrospective Study

Yea-Ji Lee1, Chung-Sik Oh1,2, Ji Min Choi1, Sangtae Park1, Seong-Hyop Kim1,2,3✉

1. Department of Anaesthesiology and Pain medicine, Konkuk University Medical Centre, Konkuk University School of Medicine, Seoul, Korea
2. Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea
3. Department of Infection and Immunology, Konkuk University School of Medicine, Seoul, Korea

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Citation:
Lee YJ, Oh CS, Choi JM, Park S, Kim SH. mu-Opioid Receptor Polymorphisms and Breast Cancer Recurrence in Adult Korean Women Undergoing Breast Cancer Surgery: A Retrospective Study. Int J Med Sci 2020; 17(18):2941-2946. doi:10.7150/ijms.49297. Available from https://www.medsci.org/v17p2941.htm

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Abstract

Background: Genetic variations of mu-opioid receptors are well known to contribute to growth and progression of tumors. The most common single-nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) is the A118G mutation. We examined the association between the recurrent breast cancer and genotypes of OPRM1 A118G SNP (AA vs. AG vs. GG) in Korean women population.

Methods: We analysed medical records and genetic data of 200 patients aged more than 20 who underwent primary breast cancer surgery from June 2012 to June 2014 and diagnosed recurrent breast cancer from June 2012 to September 2019.

Results: The incidence of recurrent breast cancer was 6.1%, 8.2%, and 4.8% in genotype AA, AG and GG, respectively (p=0.780). The incidence of recurrent breast cancer in volatile anaesthesia group was 7.0% and 7.1% in total intravenous anaesthesia (TIVA) group (RR = 0.984, 95% CI = 0.328 - 2.951; p = 0.978).

Conclusion: OPRM1 A118G SNP had no influence on breast cancer recurrence in Korean women. Anaesthesia technique did not show significant effect on the incidence of recurrent breast cancer.

Keywords: Receptors, opioid, mu, Breast neoplasms, Anaesthesia, general