Int J Med Sci 2020; 17(13):2052-2062. doi:10.7150/ijms.47935

Research Paper

Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China

Xia Xu1, Mu-Qing Yu2, Qian Shen3, Lian-Zhong Wang4, Rong-Di Yan4, Meng-Yu Zhang5, Jian-Yu Liu5, Yi-Qing Qu6✉

1. Department of Geriatric Medicine, Qilu Hospital of Shandong University.
2. Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
3. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
4. Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong University of TCM.
5. Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
6. Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University.

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Citation:
Xu X, Yu MQ, Shen Q, Wang LZ, Yan RD, Zhang MY, Liu JY, Qu YQ. Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China. Int J Med Sci 2020; 17(13):2052-2062. doi:10.7150/ijms.47935. Available from http://www.medsci.org/v17p2052.htm

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Abstract

Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity.

Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients.

Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ±15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity.

Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient.

Keywords: COVID-19, outbreak phage, clinical characteristics, inflammatory cytokines, disease severity