Int J Med Sci 2020; 17(13):2024-2030. doi:10.7150/ijms.46729

Research Paper

Two-year outcome of Trabeculo-Canalectomy for Chinese Glaucoma Patients

Zhan Xie1*, Zhao-Xia Mu1*, Mu-Long Du2, Ying-Ting Zhu3, Hong Sun1✉

1. Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
2. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
3. Tissue Tech, Inc., Miami, FL, 33126, USA.
*These authors contributed equally to this manuscript.

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Citation:
Xie Z, Mu ZX, Du ML, Zhu YT, Sun H. Two-year outcome of Trabeculo-Canalectomy for Chinese Glaucoma Patients. Int J Med Sci 2020; 17(13):2024-2030. doi:10.7150/ijms.46729. Available from http://www.medsci.org/v17p2024.htm

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Abstract

To evaluate the efficacy of trabeculo-canalectomy in treating glaucoma patients, a retrospective investigation of 53 glaucoma patients (53 eyes) who underwent trabeculo-canalectomy was conducted at the First Affiliated Hospital of Nanjing Medical University, China, from April 2017 to January 2019. Intraocular pressure (IOP), visual acuity, surgical success rates, medications, and complications were monitored at post-operative 1 day, 1 week, 1, 3, 6, 12 and 24 months. Surgical success criteria were defined as 6 mm Hg≤IOP≤21 mmHg with or without additional medications. Our results showed that average IOP was statistically significant between pre-operative visit and each follow-up visit (all P <0.05). The total success rate of trabeculo-canalectomy at 1, 3, 6, 12 and 24 months was 92.5%, 86.8%, 94.3%, 92.5% and 90.6% respectively. After 3 months post-operatively, all patients had no obvious filtering blebs. The main early complications included postoperative hyphema (7.5%), elevated IOP (5.7%) and anterior chamber exudation (3.8%), which were all cured after conservative treatment. No blebitis, shallow anterior chamber, choroidal detachment and endophthalmitis were observed. Logistic regression analysis showed that patients with secondary glaucoma were more likely to undergo surgical failure 24 months post-operatively (P= 0.008). Thus, we conclude that trabeculo-canalectomy is effective and safe for the treatment of glaucoma.

Keywords: trabeculo-canalectomy, glaucoma, IOP