Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2020; 17(13):1984-1991. doi:10.7150/ijms.44834 This issue Cite

Research Paper

Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice

Soonjae Hwang, Samnoh Hwang, Minjeong Jo, Chang Gun Lee, Ki-Jong Rhee✉

Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University MIRAE Campus, Wonju, Gangwon-do 26493, Republic of Korea.

✉ Corresponding author: Ki-Jong Rhee, Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University MIRAE Campus, Wonju, Gangwon-do 26493, Republic of Korea; Tel: +82-33-760-2445; Fax: +82-33-760-2195; E-mail:kjrheeac.kr. More

Citation:
Hwang S, Hwang S, Jo M, Lee CG, Rhee KJ. Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. Int J Med Sci 2020; 17(13):1984-1991. doi:10.7150/ijms.44834. https://www.medsci.org/v17p1984.htm
Other styles

File import instruction

Abstract

Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract characterized by inflammation. Although IBD is usually treated with anti-inflammatory agents, most of these treatments have limited efficacy. Propolis is a viscous mixture that honeybees produce by mixing saliva and honeycomb with exudate gathered from tree buds, sap flows, or other botanical sources. Although propolis has proved to ameliorate several inflammatory disorders, its therapeutic properties vary by geographical location, plant resources, bee species, and the solvents used in the extraction. In this study, we investigated the effects of Korean propolis in BALB/c mice with dextran sulfate sodium (DSS)-induced colitis. Korean propolis extract was diluted in drinking water, and the BALB/c mice were given DSS for 7 days and Korean propolis for 17 days. The mice were sacrificed on day 17. In the DSS-induced colitis model, Korean propolis significantly decreased the severity of colitis, as assessed by body weight, spleen weight, and colonic length. Furthermore, Korean propolis induced the reduction of the inflammatory cytokine KC, infiltration of immune cells, and colonic hyperplasia in mice with DSS-induced colitis. The Korean propolis also decreased the loss of goblet cells and antibody-reactivity to inflammatory markers in the colons of mice administered DSS. These results demonstrate for the first time that Korean propolis has an ameliorative effect on DSS-induced colonic inflammation in BALB/c mice.

Keywords: dextran sulfate sodium, inflammatory bowel disease, colitis, propolis

Citation styles

APA
Hwang, S., Hwang, S., Jo, M., Lee, C.G., Rhee, K.J. (2020). Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. International Journal of Medical Sciences, 17(13), 1984-1991. https://doi.org/10.7150/ijms.44834.

ACS
Hwang, S.; Hwang, S.; Jo, M.; Lee, C.G.; Rhee, K.J. Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. Int. J. Med. Sci. 2020, 17 (13), 1984-1991. DOI: 10.7150/ijms.44834.

NLM
Hwang S, Hwang S, Jo M, Lee CG, Rhee KJ. Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. Int J Med Sci 2020; 17(13):1984-1991. doi:10.7150/ijms.44834. https://www.medsci.org/v17p1984.htm

CSE
Hwang S, Hwang S, Jo M, Lee CG, Rhee KJ. 2020. Oral administration of Korean propolis extract ameliorates DSS-induced colitis in BALB/c mice. Int J Med Sci. 17(13):1984-1991.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use