Int J Med Sci 2020; 17(12):1803-1810. doi:10.7150/ijms.47836

Review

Advances and challenges in the prevention and treatment of COVID-19

Yan-Jie Han1,2,3*✉, Zhi-Guang Ren1,2*, Xin-Xin Li3, Ji-Liang Yan3, Chun-Yan Ma3, Dong-Dong Wu1,2,4✉, Xin-Ying Ji1,2✉

1. Kaifeng Key Laboratory for Infectious Diseases and Biosafety, School of Basic Medical Science, Henan University, Kaifeng, Henan 475004, China.
2. Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Science, Henan University, Kaifeng, Henan 475004, China.
3. Clinical Laboratory and Functional Laboratory, Kaifeng Central Hospital, Kaifeng, Henan 475000, China.
4. School of Stomatology, Henan University, Kaifeng, Henan 475004, China.
*These authors contributed equally in this manuscript.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Han YJ, Ren ZG, Li XX, Yan JL, Ma CY, Wu DD, Ji XY. Advances and challenges in the prevention and treatment of COVID-19. Int J Med Sci 2020; 17(12):1803-1810. doi:10.7150/ijms.47836. Available from http://www.medsci.org/v17p1803.htm

File import instruction

Abstract

Since the end of 2019, a new type of coronavirus pneumonia (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout the world. Previously, there were two outbreaks of severe coronavirus caused by different coronaviruses worldwide, namely Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This article introduced the origin, virological characteristics and epidemiological overview of SARS-CoV-2, reviewed the currently known drugs that may prevent and treat coronavirus, explained the characteristics of the new coronavirus and provided novel information for the prevention and treatment of COVID-19.

Keywords: SARS-CoV-2, COVID-19, virological characteristics, clinical treatment, drugs.