Int J Med Sci 2019; 16(12):1573-1582. doi:10.7150/ijms.38439

Research Paper

SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway

Qian Wang1, Shengnan Jia2, Yan Jiao3, Libo Xu1, Ding Wang1, Xuyang Chen1, Xindan Hu1, Hang Liang1, Naiyan Wen1, Shengnan Zhang1, Baofeng Guo4✉, Ling Zhang1✉

1. Department of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China;
2. Department of Hepatopancreatobiliary Medicine, The Second Hospital of Jilin University, Changchun 130041, P. R. China;
3. Department of Hepatobiliary and pancreatic surgery, First Hospital of Jilin University, Changchun 130021, P. R. China;
4. Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R.China.

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Citation:
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L. SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway. Int J Med Sci 2019; 16(12):1573-1582. doi:10.7150/ijms.38439. Available from http://www.medsci.org/v16p1573.htm

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Abstract

Colorectal cancer is one of the most common cancers worldwide with a high incidence rate. Therefore, the molecular basis of colorectal tumorigenesis and evolution must be clarified. Structure-specific recognition protein 1 (SSRP1) is involved in transcriptional regulation, DNA damage repair, and cell cycle regulation and has been confirmed to be highly expressed in various tumor tissues, including colorectal cancer. However, the role of SSRP1 in the development of colorectal cancer remains unclear. Therefore, this study explored the role of SSRP1 in the occurrence and development of colorectal cancer. Using bioinformatics databases, including samples from the Cancer Genome Atlas (TCGA), we confirmed high SSRP1 expression in human colorectal adenocarcinoma tissues. We demonstrated that SSRP1 knockdown via small interfering RNA significantly inhibited the proliferation of colorectal cancer cells and promoted apoptosis through the AKT signaling pathway, suppressing the invasion and migration of colorectal cancer cells in vitro and in vivo. In conclusion, this study demonstrated that SSRP1 silencing influenced the proliferation and apoptosis of colorectal cancer cells via the AKT signaling pathway.

Keywords: SSRP1, proliferation, apoptosis, AKT pathway