Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2019; 16(11):1461-1465. doi:10.7150/ijms.35789 This issue Cite

Research Paper

Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample

Bupachad Khanthiyong1,2, Samur Thanoi1,2, Gavin P. Reynolds2,3, Sutisa Nudmamud-Thanoi1,2✉

1. Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand
2. Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand
3. Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom

✉ Corresponding author: Tel: +6655964672; Fax: +6655964770; E-mail: sutisatac.th

Citation:
Khanthiyong B, Thanoi S, Reynolds GP, Nudmamud-Thanoi S. Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. Int J Med Sci 2019; 16(11):1461-1465. doi:10.7150/ijms.35789. https://www.medsci.org/v16p1461.htm
Other styles

File import instruction

Abstract

Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little work has investigated this in the Thai population and the relationship of age and education with this association remains unclear. Therefore, this study was designed to investigate the association of this polymorphism of the COMT gene with executive cognitive brain function in healthy subjects and the relationship with age and education. The Wisconsin Card Sorting Test (WCST) was performed to assess executive function in 254 healthy Thai subjects (aged 20-72 years). The results showed a significant association of rs4680 with executive function, in which Val/Met heterozygotes demonstrated better cognitive set shifting performance. Moreover, Met allele carriers showed a significantly stronger effect in the categories completed score than did Val homozygotes. Furthermore, age and education also showed a significant association with COMT genotype and WCST. These results revealed that executive cognitive function is associated with COMT genotype and influenced by age and/or education level in a Thai sample.

Keywords: Executive function, Catechol-O-Methyltranferase (COMT), Val158Met, Wisconsin Card Sorting Test (WCST), Single Nucleotide Polymorphism (SNP)

Citation styles

APA
Khanthiyong, B., Thanoi, S., Reynolds, G.P., Nudmamud-Thanoi, S. (2019). Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. International Journal of Medical Sciences, 16(11), 1461-1465. https://doi.org/10.7150/ijms.35789.

ACS
Khanthiyong, B.; Thanoi, S.; Reynolds, G.P.; Nudmamud-Thanoi, S. Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. Int. J. Med. Sci. 2019, 16 (11), 1461-1465. DOI: 10.7150/ijms.35789.

NLM
Khanthiyong B, Thanoi S, Reynolds GP, Nudmamud-Thanoi S. Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. Int J Med Sci 2019; 16(11):1461-1465. doi:10.7150/ijms.35789. https://www.medsci.org/v16p1461.htm

CSE
Khanthiyong B, Thanoi S, Reynolds GP, Nudmamud-Thanoi S. 2019. Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. Int J Med Sci. 16(11):1461-1465.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use