Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2019; 16(6):793-799. doi:10.7150/ijms.33967 This issue Cite

Research Paper

A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese

Chuang Li1,2, Dongdong Sun1,2, Jielin Liu1,2, Mei Li1,2, Bei Zhang1,2, Ya Liu1,2, Zuoguang Wang1,2, Shaojun Wen1,2,✉, Jiapeng Zhou3,4✉

1. Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Herat Lung and Blood Vessel Diseases, Beijing, People's Republic of China
2. Beijing Lab for Cardiovascular Precision Medicine, Beijing, People's Republic of China
3. College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China
4. Beijing Mygenostics Co., Ltd., Beijing, People's Republic of China

✉ Corresponding authors: Shaojun Wen, Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood vessel Diseases, 2 Anzhen Road, Chaoyang District, Beijing 100029, PR China. T More

Citation:
Li C, Sun D, Liu J, Li M, Zhang B, Liu Y, Wang Z, Wen S, Zhou J. A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese. Int J Med Sci 2019; 16(6):793-799. doi:10.7150/ijms.33967. https://www.medsci.org/v16p0793.htm
Other styles

File import instruction

Abstract

Background: Essential hypertension (EH) is a chronic disease of universal high prevalence and a well-established independent risk factor for cardiovascular and cerebrovascular events. The regulation of blood pressure is crucial for improving life quality and prognoses in patients with EH. Therefore, it is of important clinical significance to develop prediction models to recognize individuals with high risk for EH.

Methods: In total, 965 subjects were recruited. Clinical parameters and genetic information, namely EH related SNPs were collected for each individual. Traditional statistic methods such as t-test, chi-square test and multi-variable logistic regression were applied to analyze baseline information. A machine learning method, mainly support vector machine (SVM), was adopted for the development of the present prediction models for EH.

Results: Two models were constructed for prediction of systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively. The model for SBP consists of 6 environmental factors (age, BMI, waist circumference, exercise [times per week], parental history of hypertension [either or both]) and 1 SNP (rs7305099); model for DBP consists of 6 environmental factors (weight, drinking, exercise [times per week], TG, parental history of hypertension [either and both]) and 3 SNPs (rs5193, rs7305099, rs3889728). AUC are 0.673 and 0.817 for SBP and DBP model, respectively.

Conclusions: The present study identified environmental and genetic risk factors for EH in northern Han Chinese population and constructed prediction models for SBP and DBP.

Keywords: essential hypertension, prediction model, single nucleotide polymorphism, northern Han Chinese population

Citation styles

APA
Li, C., Sun, D., Liu, J., Li, M., Zhang, B., Liu, Y., Wang, Z., Wen, S., Zhou, J. (2019). A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese. International Journal of Medical Sciences, 16(6), 793-799. https://doi.org/10.7150/ijms.33967.

ACS
Li, C.; Sun, D.; Liu, J.; Li, M.; Zhang, B.; Liu, Y.; Wang, Z.; Wen, S.; Zhou, J. A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese. Int. J. Med. Sci. 2019, 16 (6), 793-799. DOI: 10.7150/ijms.33967.

NLM
Li C, Sun D, Liu J, Li M, Zhang B, Liu Y, Wang Z, Wen S, Zhou J. A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese. Int J Med Sci 2019; 16(6):793-799. doi:10.7150/ijms.33967. https://www.medsci.org/v16p0793.htm

CSE
Li C, Sun D, Liu J, Li M, Zhang B, Liu Y, Wang Z, Wen S, Zhou J. 2019. A Prediction Model of Essential Hypertension Based on Genetic and Environmental Risk Factors in Northern Han Chinese. Int J Med Sci. 16(6):793-799.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use