Int J Med Sci 2019; 16(4):548-555. doi:10.7150/ijms.30097

Review

MALAT1 as a Diagnostic and Therapeutic Target in Diabetes-Related Complications: A Promising Long-Noncoding RNA

Leila Elmi Abdulle1*, Ji-long Hao1*, Om Prakash Pant1*, Xiu-fen Liu1*, Dan-dan Zhou2*, Ying Gao3*, Abhishek Suwal1*, Cheng-wei Lu1✉

1. Department of Ophthalmology,
2. Department of Radiology,
3. Department of Endocrinology, The First Hospital of Jilin University, No. 71 of Xinmin St. Changchun, Jilin Province, 130021, China.
* Leila Elmi Abdulle, Ji-long Hao, Om Prakash Pant, Xiu-fen Liu, Dan-Dan Zhou, Ying Gao and Abhishek Suwal are co-first authors.

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Citation:
Abdulle LE, Hao Jl, Pant OP, Liu Xf, Zhou Dd, Gao Y, Suwal A, Lu Cw. MALAT1 as a Diagnostic and Therapeutic Target in Diabetes-Related Complications: A Promising Long-Noncoding RNA. Int J Med Sci 2019; 16(4):548-555. doi:10.7150/ijms.30097. Available from http://www.medsci.org/v16p0548.htm

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Abstract

Diabetes mellitus is a global issue with increasing incidence rate worldwide. In an uncontrolled case, it can advance to various organ-related complications leading to an increase in morbidity and mortality. Long non-coding RNA (lncRNA) Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) appears to be a fairly novel lncRNA that is relevant to diabetes and its role in diabetic-related diseases initiation and progression have long been a subject of attention to many scholars. The expression of MALAT1 is elevated in different diabetic-related diseases. In this review, we demonstrate the various functions of MALAT1 in the different diabetes-related complications including ischemic reperfusion injury, retinopathy, cataract, atherosclerosis, cardiomyopathy, non-alcoholic steatohepatitis, gastroparesis, kidney disease, and gestational diabetes. The emerging evidence showed that the role of MALAT1 in diabetic-related complications is both pro-inflammatory and apoptosis in different cell types. These results concluded that MALAT1 is a potential diagnostic and future targeted therapy for diabetes-associated complications.

Keywords: diabetes mellitus, diabetes-related complications, long non-coding RNA, MALAT1