Int J Med Sci 2018; 15(12):1286-1295. doi:10.7150/ijms.27087


Cannabinoids: from pot to lab

Esther Papaseit1,2, Clara Pérez-Mañá1,2, Ana Pilar Pérez-Acevedo1,2, Olga Hladun1,2, M. Carmen Torres-Moreno1,2, Robert Muga2,3, Marta Torrens2,4, Magí Farré1,2✉

1. Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona (Spain).
2. Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Barcelona (Spain).
3. Internal Medicine Department, Universitari Germans Trias i Pujol (HUGTP-IGTP), Badalona (Spain).
4. Drug Addiction Program, Institut de Neuropsiquiatria i Adiccions (INAD), Parc de Salut Mar, Barcelona (Spain).

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Papaseit E, Pérez-Mañá C, Pérez-Acevedo AP, Hladun O, Torres-Moreno MC, Muga R, Torrens M, Farré M. Cannabinoids: from pot to lab. Int J Med Sci 2018; 15(12):1286-1295. doi:10.7150/ijms.27087. Available from

File import instruction


Cannabis is becoming increasingly present in our society. In recent years, the line between the natural (cannabis) and the synthetic (synthetic cannabinoids), the recreational (cannabis) and the medical (pharmaceutical cannabinoids and medical cannabis) has been crossed. In this paper we review some of the novel aspects of cannabis and cannabinoids in relation to their legal situation, changes in their composition and forms of cannabis use, the concept of medical cannabis, and synthetic cannabinoids as new psychoactive substances (NPS). We have also analyzed serious adverse reactions and intoxications associated with the use of synthetic cannabinoids, as well as the latest developments in the research of pharmaceutical cannabinoids.

Keywords: Cannabis, Delta-9-tetrahydrocannabinol (THC), Cannabidiol (CBD), Medical cannabis, Synthetic cannabinoid