Int J Med Sci 2018; 15(9):892-899. doi:10.7150/ijms.24042 This issue Cite

Research Paper

A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation

Lei Geng1,2,3,*, Jingfeng Liu1,2,3,*, Junjie Huang1,2,3, Bingyi Lin1,2,3, Songfeng Yu1,2,3, Tian Shen1,2,3, Zhuoyi Wang1,2,3, Zhe Yang1,2,3, Lin Zhou1,2,3, Shuseng Zheng1,2,3,✉

1. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
2. Division of Liver Transplantation, Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
*These authors contribute equally to the study.

Citation:
Geng L, Liu J, Huang J, Lin B, Yu S, Shen T, Wang Z, Yang Z, Zhou L, Zheng S. A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation. Int J Med Sci 2018; 15(9):892-899. doi:10.7150/ijms.24042. https://www.medsci.org/v15p0892.htm
Other styles

File import instruction

Abstract

CD8+CD28-T cells (CD8Ts) exert immunosuppressive effects in various autoimmune diseases. The current study was designed to investigate the role of defects in CD8Ts in liver transplantation (LT). The proportion of CD8Ts in peripheral blood was determined by flow cytometry. The mean proportion of CD8Ts was 23.39% in recipients with stable graft function and 16.64% in those with graft dysfunction following LT compared with 19.86% in the healthy cohort. After receiving enhanced immunosuppressive therapy, patients in the rejection group who achieved recovery of graft function showed an increase in the proportion of CD8Ts (from 17.39% to 25.55%), but those in the group with refractory graft dysfunction showed no significant change (12.49% to 10.30%). Furthermore, in the first year after LT, recipients longer removed in time from the LT date exhibited a higher proportion of CD8Ts. Patients benefited most from tacrolimus concentrations of 5-10 ng/ml in the first year after LT and 0-5 ng/ml thereafter. Moreover, the change in the proportion of CD8Ts (ΔCD8Ts) was significantly higher in recipients with stable graft function than in those with graft dysfunction. These results suggest that a high frequency of CD8Ts prevents rejection and contributes to reduce immunosuppressant dosage and even induces tolerance.

Keywords: CD8+CD28-T cells, Liver transplantation, Tacrolimus, Rejection


Citation styles

APA
Geng, L., Liu, J., Huang, J., Lin, B., Yu, S., Shen, T., Wang, Z., Yang, Z., Zhou, L., Zheng, S. (2018). A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation. International Journal of Medical Sciences, 15(9), 892-899. https://doi.org/10.7150/ijms.24042.

ACS
Geng, L.; Liu, J.; Huang, J.; Lin, B.; Yu, S.; Shen, T.; Wang, Z.; Yang, Z.; Zhou, L.; Zheng, S. A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation. Int. J. Med. Sci. 2018, 15 (9), 892-899. DOI: 10.7150/ijms.24042.

NLM
Geng L, Liu J, Huang J, Lin B, Yu S, Shen T, Wang Z, Yang Z, Zhou L, Zheng S. A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation. Int J Med Sci 2018; 15(9):892-899. doi:10.7150/ijms.24042. https://www.medsci.org/v15p0892.htm

CSE
Geng L, Liu J, Huang J, Lin B, Yu S, Shen T, Wang Z, Yang Z, Zhou L, Zheng S. 2018. A high frequency of CD8+CD28- T-suppressor cells contributes to maintaining stable graft function and reducing immunosuppressant dosage after liver transplantation. Int J Med Sci. 15(9):892-899.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image