Int J Med Sci 2018; 15(5):517-527. doi:10.7150/ijms.22454

Research Paper

Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression

Chunyan Yang1*, Dongming Zhao1,2*, Guohui Liu1, Haikuo Zheng1, Hongliang Yang1, Sibao Yang1, Ping Yang1✉

1. Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, 130033, China
2. Department of Cardiology, the affiliated hospital of Beihua University, Jilin, China
* These authors contributed equally to this work

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Yang C, Zhao D, Liu G, Zheng H, Yang H, Yang S, Yang P. Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression. Int J Med Sci 2018; 15(5):517-527. doi:10.7150/ijms.22454. Available from

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Uncoupling protein 2 (UCP2) is primarily expressed in the myocardium and is closely related to myocardial ischemia/reperfusion injury and myocardial metabolism. To explore the effects and the mechanisms of UCP2 on atorvastatin-mediated myocardium protection, the rat model of myocardial ischemia was established by ligation of the left anterior descending coronary arteries (LADs). The rats were divided into the sham operation (SO) group, myocardial infarction (MI) group and MI-atorvastatin group. The study that atorvastatin reduced myocardial remodeling and improved the disturbed myocardial energy metabolism after MI. Furthermore, the mechanisms of myocardial metabolic remodeling affected by atorvastatin were explored. The atorvastatin group showed a significantly decreased expression of UCP2 mRNA and protein. Furthermore, the primary rat cardiomyocytes were cultured and treated with angiotensin II (Ang II) to induce cardiomyocyte hypertrophy. The results showed that in the atorvastatin group, the surface area of the cardiomyocytes, the total protein content per unit of cells, and the expression of the UCP2 protein were significantly decreased. These data suggested that atorvastatin significantly attenuated the myocardial remodeling by downregulating the expression of UCP2 that was found to improve the myocardial energy metabolism, inhibit myocardial hypertrophy, and eventually reduce myocardial remodeling

Keywords: atorvastatin, heart failure, uncoupling proteins-2, metabolic remodeling