Int J Med Sci 2018; 15(5):430-435. doi:10.7150/ijms.23428
DJ-1 in Ocular Diseases: A Review
Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
*Cong Liu and Xiufen Liu contribute equally to this manuscript.
Liu C, Liu X, Qi J, Pant OP, Lu Cw, Hao J. DJ-1 in Ocular Diseases: A Review. Int J Med Sci 2018; 15(5):430-435. doi:10.7150/ijms.23428. Available from http://www.medsci.org/v15p0430.htm
Protein deglycase DJ-1 (Parkinson disease protein 7) is a 20 kDa protein encoded by PARK7 gene. It is also known as a redox-sensitive chaperone and sensor that protect cells against oxidative stress-induced cell death in many human diseases. Though increasing evidence implicates that DJ-1 may also participate in ocular diseases, the overview of DJ-1 in ocular diseases remains elusive. In this review, we discuss the role as well as the underlying molecular mechanisms of DJ-1 in ocular diseases, including Fuchs endothelial corneal dystrophy (FECD), age-related macular degeneration (AMD), cataracts, and ocular neurodegenerative diseases, highlighting that DJ-1 may serve as a very striking therapeutic target for ocular diseases.
Keywords: DJ-1, ocular disease, oxidative stress