1. Department of Thoracic Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China;
2. Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan;
3. Department of Thoracic Surgery, Changhua Christian Hospital, Changhua, Taiwan;
4. Department of Nursing, National Taichung University of Science and Technology, Taichung, Taiwan;
5. Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan;
6. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China;
7. Department of Respiratory Therapy, Fu-Jen Catholic University, New Taipei City, Taiwan;
8. School of Medicine, China Medical University, Taichung, Taiwan.
Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population.
Keywords: HMGB1, Lung cancer, SNP, Susceptibility, Polymorphisms, Chinese Han.