ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2016; 13(4):304-309. doi:10.7150/ijms.14877 This issue Cite
Research Paper
Effects of HMGB1 Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma
1. Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
2. Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan
3. Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
4. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
5. Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
6. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
7. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
8. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
9. Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan
10. Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan
11. Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan
Abstract
Hepatocellular carcinoma (HCC) is a malignancy of liver and a leading cause of cancer mortality worldwide. Its management is compounded by biological and clinical heterogeneity. These interindividual genetic variations can modulate the effects of HCC treatment. High-mobility group box protein 1 (HMGB1) is a well investigated, ubiquitous nuclear protein found in eukaryotic cells that plays a multiple biological roles such as DNA stability, program cell death, immune response, and furthermore in cancer progression. In this report, we examined HMGB1 single nucleotide polymorphisms (SNPs) with multiple risk factors related to HCC susceptibility and clinicopathological characteristics. Four HMGB1 SNPs (rs1412125, rs2249825, rs1045411, and rs1360485) were assessed by using a TaqMan SNPs Genotyping in 324 patients with HCC and in 695 cancer-free controls. The results showed that HMGB1 SNP rs1045411 with CT or at least one T alleles has lower risk of HCC than wild-type (CC) carriers. Moreover, HMGB1 SNP rs1412125 with TT allele has a higher risk of distant metastasis compared with patients carrying at least one C allele. The present study is the first report to discuss the risk factors associated with HMGB1 SNPs in HCC progression in Taiwan.
Keywords: HMGB1, HCC, SNP, Susceptibility
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