Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2015; 12(12):995-999. doi:10.7150/ijms.13193 This issue Cite

Short Research Communication

Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

Jan A. Graw#, Clarissa von Haefen#, Deniz Poyraz, Nadine Möbius, Marco Sifringer, Claudia D. Spies✉

Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
# Jan A. Graw and Clarissa von Haefen contributed equally to this work

✉ Corresponding author: Claudia D. Spies, MD, Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germ More

Citation:
Graw JA, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies CD. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci 2015; 12(12):995-999. doi:10.7150/ijms.13193. https://www.medsci.org/v12p0995.htm
Other styles

File import instruction

Abstract

Uncoupling proteins (UCPs) are anion channels that can decouple the mitochondrial respiratory chain. "Mild uncoupling" of internal respiration reduces free radical production and oxidative cell stress. Chronic alcohol consumption is a potent inducer of oxidative stress in multiple tissues and regulates UCP-2 and -4 expression in the brain. To analyse the impact of chronic alcohol intake on UCP-2 expression in tissues with high endogenous UCP-2 contents, male Wistar rats (n=34) were treated with a 12-week 5% alcohol diet. In the lungs and the spleen of rats with a chronic alcohol diet cytochrome c release from mitochondria was significantly increased. Both organs did not show any altered gene and protein expression of UCP-2. Different to cerebral tissue chronic alcohol consumption has no regulatory effect on UCP-2 gene and protein expression in organs with a high endogenous UCP-2 content. Therefore, chronic alcohol consumption leads to a tissue specific expression of UCP-2.

Keywords: Chronic alcohol consumption, Uncoupling proteins, Cytochrome c, reactive oxygen species

Citation styles

APA
Graw, J.A., von Haefen, C., Poyraz, D., Möbius, N., Sifringer, M., Spies, C.D. (2015). Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. International Journal of Medical Sciences, 12(12), 995-999. https://doi.org/10.7150/ijms.13193.

ACS
Graw, J.A.; von Haefen, C.; Poyraz, D.; Möbius, N.; Sifringer, M.; Spies, C.D. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int. J. Med. Sci. 2015, 12 (12), 995-999. DOI: 10.7150/ijms.13193.

NLM
Graw JA, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies CD. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci 2015; 12(12):995-999. doi:10.7150/ijms.13193. https://www.medsci.org/v12p0995.htm

CSE
Graw JA, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies CD. 2015. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci. 12(12):995-999.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use