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Int J Med Sci 2015; 12(11):840-847. doi:10.7150/ijms.11579 This issue Cite

Review

Role and New Insights of Pirfenidone in Fibrotic Diseases

David Alejandro Lopez-de la Mora¹, Cibeles Sanchez-Roque¹, Margarita Montoya-Buelna¹, Sergio Sanchez-Enriquez¹, Silvia Lucano-Landeros¹, Jose Macias-Barragan^1,2, Juan Armendariz-Borunda^{1, ✉}

1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
2. Departamento de Ciencias de la Salud, CUValles, University of Guadalajara, Guadalajara - Ameca km. 45.5, Ameca (46600), Mexico.

✉ Corresponding author: armdbocom

Abstract

Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs. Basic and clinical evidence suggests that PFD may safely slow or inhibit the progressive fibrosis swelling after tissue injuries. Furthermore, a number of evidence suggests that this molecule will have positive effects in the treatment of other inflammatory diseases. This review contains current research in which PFD has been used as the treatment of several diseases, and focus mainly in the outcomes related to improve inflammation and fibrogenesis. Therefore, the main goal of this review is to focus on the novel findings of PFD efficacy rather than deepen in the chemical aspects of the molecule.

Keywords: Pirfenidone, fibrosis, inflammation, idiopathic pulmonary fibrosis

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