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Int J Med Sci 2015; 12(9):701-707. doi:10.7150/ijms.12658 This issue Cite

Review

Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering

Kiat Hwa Chan², Shuangmu Zhuo^1✉, Ming Ni^3✉

1. Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China
2. Institute of Bioengineering and Nanotechnology, Nanos, Singapore 138669, Singapore
3. Institute of Bioengineering and Nanotechnology, Nanos, Singapore 138669, Singapore

✉ Corresponding authors: shuangmuzhuocom or mingni.sgcom

Abstract

The development of better orthopedic implants is incessant. While current implants can function reliably in the human body for a long period of time, there are still a significant number of cases for which the implants can fail prematurely due to poor osseointegration of the implant with native bone. Increasingly, it is recognized that it is extremely important to facilitate the attachment of osteoblasts on the implant so that a proper foundation of extracellular matrix (ECM) can be laid down for the growth of new bone tissue. In order to facilitate the osseointegration of the implant, both the physical nanotopography and chemical functionalization of the implant surface have to be optimized. In this short review, however, we explore how simple chemistry procedures can be used to functionalize the surfaces of three major classes of orthopedic implants, i.e. ceramics, metals, and polymers, so that the attachment of osteoblasts on implants can be facilitated in order to promote implant osseointegration.

Keywords: orthopedic implant, osseointegration

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