Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761

Short Research Communication

Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

Paola Aulino1,2#, Alessandra Costa1,3,4#, Ernesto Chiaravalloti2, Barbara Perniconi2,5, Sergio Adamo1, Dario Coletti2,5, Massimo Marrelli2, Marco Tatullo2,6#✉, Laura Teodori3,7#

1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy
3. Fondazione San Raffaele, Ceglie Messapica, Italy
4. Department of Surgery, McGowan Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
5. UMR 8256 CNRS Biology of Adaptation and Aging, University Pierre et Marie Curie Paris 06, Paris, France
6. Tecnologica Research Institute, Biomedical Section, Crotone, Italy
7. UTAPRAD-DIM, ENEA Frascati, Rome, Italy
# These authors equally contributed.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Aulino P, Costa A, Chiaravalloti E, Perniconi B, Adamo S, Coletti D, Marrelli M, Tatullo M, Teodori L. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761. Available from

File import instruction


The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.

Keywords: ECM scaffold, tissue engineering, skeletal muscle, bone, cartilage