Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761
Short Research Communication
Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy
3. Fondazione San Raffaele, Ceglie Messapica, Italy
4. Department of Surgery, McGowan Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
5. UMR 8256 CNRS Biology of Adaptation and Aging, University Pierre et Marie Curie Paris 06, Paris, France
6. Tecnologica Research Institute, Biomedical Section, Crotone, Italy
7. UTAPRAD-DIM, ENEA Frascati, Rome, Italy
# These authors equally contributed.
Aulino P, Costa A, Chiaravalloti E, Perniconi B, Adamo S, Coletti D, Marrelli M, Tatullo M, Teodori L. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. Int J Med Sci 2015; 12(4):336-340. doi:10.7150/ijms.10761. Available from http://www.medsci.org/v12p0336.htm
The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.
Keywords: ECM scaffold, tissue engineering, skeletal muscle, bone, cartilage