FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis

Chen, Zhixin; Xie, Bao; Zhu, Qinhua; Xia, Qinghai; Jiang, Songmin; Cao, Ruoyu; Shi, Lihua; Qi, Dansi; Li, Xiaokun; Cai, Lin

doi:10.7150/ijms.6868

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Int J Med Sci 2013; 10(13):1868-1875. doi:10.7150/ijms.6868 This issue Cite

Research Paper

FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis

Zhixin Chen^*1, Bao Xie^{*1, 2}, Qinhua Zhu^*1, Qinghai Xia^*1, Songmin Jiang^*3, Ruoyu Cao^*4, Lihua Shi¹, Dansi Qi², Xiaokun Li¹, Lin Cai^1✉

1. Department of Biopharmaceutics, School of Pharmacy, Wenzhou Medical University, Zhejiang, Wenzhou (China)
2. Department of Pathology, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou (China)
3. Department of Pharmacy, Wenzhou Ruian People's Hospital, Zhejiang, Wenzhou (China)
4. Department of Pediatrics, Cangzhou Central Hospital, Hebei, Cangzhou (China).
* These authors contributed equally to this work.

Citation:

Chen Z, Xie B, Zhu Q, Xia Q, Jiang S, Cao R, Shi L, Qi D, Li X, Cai L. FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis. Int J Med Sci 2013; 10(13):1868-1875. doi:10.7150/ijms.6868. https://www.medsci.org/v10p1868.htm

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Abstract

Objective: To investigate the expression and correlation of transforming growth factor-β1 (TGF-β1) and fibroblast growth factor receptor 4 (FGFR4) in human hepatocellular carcinoma (HCC) and the relationship with clinicopathological features and prognosis.

Materials and methods: The expression of TGF-β1 and FGFR4 in 126 HCC samples was detected immunohistochemically. Combined with clinical postoperative follow-up data, the expression of TGF-β1 and FGFR4 in HCC and the relationship with the prognosis of patients were analyzed by statistically.

Results: The positive expression rate of TGF-β1 was 84.1% (106/126) in tumors, and that in peritumoral liver tissues was 64.3% (81/126); the positive expression rate of FGFR4 in tumors was 74.6% (94/126) and that in peritumoral liver tissues was 57.1% (72/126). The expression of TGF-β1 and FGFR4 in the carcinoma tissues was significantly higher than that in peritumoral liver tissues (p < 0.05). Intratumoral TGF-β1 and FGFR4 expression was associated with TNM stage (p < 0.05). TGF-β1 and FGFR4 expression levels didn't significantly correlate with other clinicopathological parameters, including age, sex, tumor size, serum AFP level, tumor differentiation, lymph node metastasis, etc. (p > 0.05). TGF-β1 expression was positively correlated with FGFR4 expression (r = 0.595, p < 0.05). Patients with positive FGFR4 or TGF-β1 expression had shorter overall survival compared with negative expression (p < 0.05).

Conclusions: The expression of TGF-β1 and FGFR4 could make synergy on the occurrence and progression of HCC, and may be used as prognosis indicators for HCC patients.

Keywords: TGF-β1, FGFR4, hepatocellular carcinoma, immunohistochemistry, prognosis.

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APA

Chen, Z., Xie, B., Zhu, Q., Xia, Q., Jiang, S., Cao, R., Shi, L., Qi, D., Li, X., Cai, L. (2013). FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis. International Journal of Medical Sciences, 10(13), 1868-1875. https://doi.org/10.7150/ijms.6868.

ACS

Chen, Z.; Xie, B.; Zhu, Q.; Xia, Q.; Jiang, S.; Cao, R.; Shi, L.; Qi, D.; Li, X.; Cai, L. FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis. Int. J. Med. Sci. 2013, 10 (13), 1868-1875. DOI: 10.7150/ijms.6868.

NLM

CSE

Chen Z, Xie B, Zhu Q, Xia Q, Jiang S, Cao R, Shi L, Qi D, Li X, Cai L. 2013. FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis. Int J Med Sci. 10(13):1868-1875.

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