Int J Med Sci 2013; 10(12):1649-1657. doi:10.7150/ijms.6395


Mammalian Sperm Fertility Related Proteins

Ali Ashrafzadeh1, Saiful Anuar Karsani2, Sheila Nathan1✉

1. School of Biosciences and Biotechnology, Faculty of Science and Technology, University Kebangsaan Malaysia, Selangor, Malaysia;
2. Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Ashrafzadeh A, Karsani SA, Nathan S. Mammalian Sperm Fertility Related Proteins. Int J Med Sci 2013; 10(12):1649-1657. doi:10.7150/ijms.6395. Available from

File import instruction


Infertility is an important aspect of human and animal reproduction and still presents with much etiological ambiguity. As fifty percent of infertility is related to the male partner, molecular investigations on sperm and seminal plasma can lead to new knowledge on male infertility. Several comparisons between fertile and infertile human and other species sperm proteome have shown the existence of potential fertility markers. These proteins have been categorized into energy related, structural and other functional proteins which play a major role in sperm motility, capacitation and sperm-oocyte binding. The data from these studies show the impact of sperm proteome studies on identifying different valuable markers for fertility screening. In this article, we review recent development in unraveling sperm fertility related proteins.

Keywords: proteomics, sperm, fertility, protein, infertility.