1. Dokuz Eylul University School of Medicine, Department of Internal Medicine, Izmir, Turkey;
2. Adnan Menderes University School of Medicine, Department of Biochemistry, Aydin, Turkey;
3. Adnan Menderes University, Bilim ve Teknoloji Araştırma ve Uygulama Merkezi (ADU-BILTEM), Aydin, Turkey.
Objective: To determine the level of macrophage migration inhibitory factor (MIF), its relationship with Mediterranean fever (MEFV) gene mutations and oxidative stress in familial Mediterranean fever (FMF).
Methods: Fifty one unrelated attack free FMF patients (24 M and 27 F, 32.8±8.7 years) and 30 healthy controls (16 M and 14 F, 32.7±7 years) were included in the study. Serum MIF, total oxidant status (TOS) and total anti-oxidant status (TAS) were studied.
Results: Age, sex distribution, anthropometrical indices, smoking status, serum lipids and TAS concentrations were similar between the patients and controls. However; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MIF, and TOS were significantly higher in the patients' group compared with healthy subjects. MIF, TOS and TAS levels were not different between patients with or without M694V mutations.
Conclusion: We found increased concentrations of MIF in patients with FMF. Increased MIF levels were significantly correlated with oxidative stress and in regression analysis MIF concentrations were independent from the inflammatory activity as assessed by ESR and CRP. M694V mutations seem no effect on MIF and oxidative stress.
Keywords: Macrophage migration inhibitory factors, Familial Mediterranean fever, Oxidative stress, Inflammation.