Int J Med Sci 2012; 9(4):262-268. doi:10.7150/ijms.4243

Research Paper

Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling

Firat Selvi1✉, Merva Soluk Tekkesin2, Sirmahan Cakarer1, S. Cemil Isler1, Cengizhan Keskin1

1. Istanbul University, Dentistry Faculty, Department of Oral and Maxillofacial Surgery, Istanbul, Turkey.
2. Istanbul University, Institute of Oncology, Department of Tumor Pathology & Cytology, Istanbul, Turkey.

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Selvi F, Tekkesin MS, Cakarer S, Isler SC, Keskin C. Keratocystic Odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNOR Labelling. Int J Med Sci 2012; 9(4):262-268. doi:10.7150/ijms.4243. Available from

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Purpose: The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers.

Materials and Methods: 22 KCOTs were evaluated retrospectively. The actual proliferative activity of the KCOT was measured by Ki-67 labelling index and argyrophilic nucleolar organizing regions AgNOR count per nucleus. Results: Recurrence occurred in 3 patients (13.6%) during the follow-up period (mean follow-up, 37.8 months) The Ki-67 and AgNOR counts were significantly higher in the recurrent lesions comparing to the non-recurrent lesions. (p=0,045; p=0,049) The correlation between Ki-67 and AgNOR counts was found to be positive (r=0,853 p=0,0001).

Conclusion: Within the limit of the present study, it is thought that Ki-67 and AgNOR might be helpful as a prognostic marker for the recurrences of KCOTs. These markers reinforced the meaning of the new classification of the lesion as an odontogenic tumor. Enucleation with curettage or decompression following enucleation with curettage is a simple and appropriate surgical model for the treatment of KCOT despite the relative high recurrence rate. On the other hand, the conservative treatment can be chosen only if there is no coronoid invasion, no interruptive cortical lysis and no tissular invasion.

Keywords: keratocystic odontogenic tumors, Ki-67, AgNOR