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Int J Med Sci 2011; 8(7):523-528. doi:10.7150/ijms.8.523 This issue Cite

Research Paper

Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder

Cem Gokcen^1✉, Nadir Kocak², Ahmet Pekgor³

1. Department of Child and Adolescent Psychiatry, Medicine Faculty of Gaziantep University, Gaziantep, Turkey
2. Department of Genetics, Medicine Faculty of Selcuk University, Konya, Turkey
3. Department of Statistics Faculty of Science, Selcuk University, Konya, Turkey

✉ Corresponding author: Cem Gokcen, MD, Assistance Prof, Department of Child and Adolescent Psychiatry, Medicine Faculty of Gaziantep University, Gaziantep/Turkey. E-mail: cemgokcenedu.tr; Tel: +90 342 3606060; Fax: +90 342 360 39 28

Abstract

Objective: The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children.

Study Design: MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms.

Results: Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033).

Conclusions: Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.

Keywords: Attention deficit-hyperactivity disorder, methylenetetrahydrofolate reductase gene polymorphism, folic acide

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