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Int J Med Sci 2006; 3(3):108-111. doi:10.7150/ijms.3.108 This issue Cite

Research Paper

Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women

Jens Aberle, Inga Hopfer, Frank Ulrich Beil, Udo Seedorf

Zentrum für Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany

Citation:
Aberle J, Hopfer I, Beil FU, Seedorf U. Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. Int J Med Sci 2006; 3(3):108-111. doi:10.7150/ijms.3.108. https://www.medsci.org/v03p0108.htm
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Abstract

Background: The +T294C polymorphism in PPARδ represents a functional SNP affecting transcriptional activity of the PPARδ gene. To address whether this polymorphism is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we studied a group of 967 female patients with hyperlipidaemia in the presence (n=453) or absence (n=514) of coronary heart disease.

Methods: 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction (MS-PCR). Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables.

Results: A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. Moreover, a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group, trends towards higher VLDL and LDL levels were observed.

Conclusions: Our data show for the first time that the PPARδ +T294C polymorphism is associated with lipid levels and coronary heart disease in women. However, the molecular mechanism of action remains to be elucidated.

Keywords: PPARδ, +T294C, coronary heart disease

Citation styles

APA
Aberle, J., Hopfer, I., Beil, F.U., Seedorf, U. (2006). Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. International Journal of Medical Sciences, 3(3), 108-111. https://doi.org/10.7150/ijms.3.108.

ACS
Aberle, J.; Hopfer, I.; Beil, F.U.; Seedorf, U. Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. Int. J. Med. Sci. 2006, 3 (3), 108-111. DOI: 10.7150/ijms.3.108.

NLM
Aberle J, Hopfer I, Beil FU, Seedorf U. Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. Int J Med Sci 2006; 3(3):108-111. doi:10.7150/ijms.3.108. https://www.medsci.org/v03p0108.htm

CSE
Aberle J, Hopfer I, Beil FU, Seedorf U. 2006. Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women. Int J Med Sci. 3(3):108-111.

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