Int J Med Sci 2024; 21(8):1500-1510. doi:10.7150/ijms.95984 This issue Cite

Research Paper

Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis

Xiaopan Liu1*, Ning Wu2*, Jian Li1, Meng Pang1, Yaozhen Wang1, Yuge Wang3, Shuai Jia1, Yanqiang Wang1✉

1. Department of Neurology II, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
2. Ward 1, Department of Critical Care Medicine, Lin Yi Central Hospital, Lin Yi, Shandong, China.
3. Department of Neurology, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, China.
*These authors contributed equally to this work.

Citation:
Liu X, Wu N, Li J, Pang M, Wang Y, Wang Y, Jia S, Wang Y. Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis. Int J Med Sci 2024; 21(8):1500-1510. doi:10.7150/ijms.95984. https://www.medsci.org/v21p1500.htm
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Abstract

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Background: Previous studies have mostly investigated the risk factors affecting the occurrence of leukoaraiosis and the risk factors affecting the severity of leukoaraiosis in patients with ischemic stroke, but there are relatively few studies on the risk factors and clinical characteristics affecting the severity of leukoaraiosis in the population with the most common type of first-episode ischemic stroke caused by intracranial atherosclerotic stenosis in China.

Methods: We retrospectively studied patients with first-ever ischemic stroke due to intracranial atherosclerotic stenosis. All patients underwent diffusion weight magnetic resonance imaging and adjunctive examinations such as magnetic resonance angiography and/or computed tomography angiography and/or digital subtraction angiography. The characteristics and clinical data were also statistically analyzed.

Results: Of the 504 patients enrolled, 176 (34.92%), 202 (40.08%), and 126 (25.00%) patients were in the mild, moderate, and severe groups, respectively, and the patients were older in the severe group compared with the moderate and mild groups (p < 0.05). Hypertension was more severe in the severe group compared with the severe and mild groups (p < 0.05). The time to hospital admission was shorter in the severe group compared with the moderate and mild groups (p < 0.05). The admission National Institutes of Health stroke scale was higher in the severe group than in the moderate and mild groups (p < 0.05). homocysteine, glucose, glycohemoglobin A1c, neutrophil-lymphocyte ratio, and ultrasensitive C-reactive protein to albumin ratio levels were significantly different between the three groups (p < 0.05). There was no significant correlation between the distribution of infarct foci in the anterior and posterior circulation in the three groups (p > 0.05).

Conclusion: Age and homocysteine were independent risk factors for leukoaraiosis severity in patients with acute ischemic stroke, and all were positively associated with leukoaraiosis severity. Hypertension, glucose, glycohemoglobin A1c, neutrophil-lymphocyte ratio and ultrasensitive C-reactive protein to albumin ratio levels were highly significant in evaluating the prognosis of patients.

Keywords: ischemic stroke, leukoaraiosis, intracranial atherosclerotic stenosis, clinical features, risk factors, pathogenesis


Citation styles

APA
Liu, X., Wu, N., Li, J., Pang, M., Wang, Y., Wang, Y., Jia, S., Wang, Y. (2024). Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis. International Journal of Medical Sciences, 21(8), 1500-1510. https://doi.org/10.7150/ijms.95984.

ACS
Liu, X.; Wu, N.; Li, J.; Pang, M.; Wang, Y.; Wang, Y.; Jia, S.; Wang, Y. Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis. Int. J. Med. Sci. 2024, 21 (8), 1500-1510. DOI: 10.7150/ijms.95984.

NLM
Liu X, Wu N, Li J, Pang M, Wang Y, Wang Y, Jia S, Wang Y. Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis. Int J Med Sci 2024; 21(8):1500-1510. doi:10.7150/ijms.95984. https://www.medsci.org/v21p1500.htm

CSE
Liu X, Wu N, Li J, Pang M, Wang Y, Wang Y, Jia S, Wang Y. 2024. Risk Factors and Clinical Characteristics of First-ever Ischemic Stroke Caused by ICAS with Leukoaraiosis. Int J Med Sci. 21(8):1500-1510.

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