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Int J Med Sci 2023; 20(3):346-358. doi:10.7150/ijms.80329 This issue Cite

Research Paper

Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology

Junmin Wang1,2, Yifei Lu2, Caiyun Zhang2, Shuxia Tian1, Hongjiao Xiang2, Peilun Ding2, Junming Chen1✉, Guang Ji3✉, Tao Wu2✉

1. Minhang Hospital, Fudan University, Shanghai 201199, China.
2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
3. Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

✉ Corresponding authors: Prof. Junming Chen, PhD. Minhang Hospital, Fudan University, Xinsong Road 170, Shanghai 201199, China. Tel: +86-18930174505, E-mail: chjm2008com; Prof. Guang Ji, PhD. Institute of Digestive Disease, Longhua Hospital, Shan More

Citation:
Wang J, Lu Y, Zhang C, Tian S, Xiang H, Ding P, Chen J, Ji G, Wu T. Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. Int J Med Sci 2023; 20(3):346-358. doi:10.7150/ijms.80329. https://www.medsci.org/v20p0346.htm
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Abstract

Graphic abstract

Qinggan Huoxue Recipe (QGHXR) is originated from Xiao Chaihu Decotion. Many experimental studies have confirmed that QGHXR can significantly alleviate the symptoms of alcoholic liver disease (ALD), but the detailed mechanism is still unclear. Using traditional Chinese medicine network pharmacology analysis system database and animal experiments, we found that 180 potentially chemical compositions and 618 potential targets were screened from the prescription, which shared 133 signal pathways with ALD. Through animal experiments, it was found that QGHXR could reduce the liver total cholesterol (TC), serum TC, alanine aminotransferase, aspartate aminotransferase of ALD mice, reduce the lipid droplets and inflammatory injury of liver tissue. Meanwhile, it can also increase PTEN, decrease PI3K and AKT mRNA levels. In this study, we obtained the targets and pathways of QGHXR in the treatment of ALD, and preliminatively verified that QGHXR may improve ALD through PTEN/PI3K/AKT signaling pathway.

Keywords: qinggan huoxue recipe, alcoholic liver disease, network pharmacology, PTEN/PI3K/AKT, traditional Chinese medicine

Citation styles

APA
Wang, J., Lu, Y., Zhang, C., Tian, S., Xiang, H., Ding, P., Chen, J., Ji, G., Wu, T. (2023). Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. International Journal of Medical Sciences, 20(3), 346-358. https://doi.org/10.7150/ijms.80329.

ACS
Wang, J.; Lu, Y.; Zhang, C.; Tian, S.; Xiang, H.; Ding, P.; Chen, J.; Ji, G.; Wu, T. Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. Int. J. Med. Sci. 2023, 20 (3), 346-358. DOI: 10.7150/ijms.80329.

NLM
Wang J, Lu Y, Zhang C, Tian S, Xiang H, Ding P, Chen J, Ji G, Wu T. Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. Int J Med Sci 2023; 20(3):346-358. doi:10.7150/ijms.80329. https://www.medsci.org/v20p0346.htm

CSE
Wang J, Lu Y, Zhang C, Tian S, Xiang H, Ding P, Chen J, Ji G, Wu T. 2023. Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. Int J Med Sci. 20(3):346-358.

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