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Int J Med Sci 2023; 20(1):151-162. doi:10.7150/ijms.79116 This issue Cite

Review

Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages

Yuliang Wang1*✉, Yiyin Long1*, Feng Wang2*, Changlin Li1*, Wei Liu3✉

1. Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China
2. Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
3. Tianjin Children's Hospital, Children's Hospital, Tianjin University, Tianjin, China
* These authors contributed equally to this work.

✉ Corresponding authors: Wei Liu, Tianjin Children's Hospital, Children's Hospital, Tianjin University, Tianjin, China. E-mail: lance1971com; Yuliang Wang, The Tianjin Institute of Urology, Second Hospital of Tianjin Medical University, Tianjin, More

Citation:
Wang Y, Long Y, Wang F, Li C, Liu W. Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages. Int J Med Sci 2023; 20(1):151-162. doi:10.7150/ijms.79116. https://www.medsci.org/v20p0151.htm
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Abstract

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The SARS-CoV-2 Omicron is currently the predominant circulating variant in the COVID-19 pandemic. The dominating Omicron sublineages respond to host immune pressure and develop advantageous mutations or genetic recombination, which result in variants that are more contagious or better at escaping immune responses in response to previous infection or vaccination. Meanwhile, multiple genetic recombination events have been reported in coinfection cases, the majority of which have resulted from the recombination between co-circulating Omicron BA.1 (or BA.1.1) and Delta variant or BA.2. Here, we review the knowledge and characterization of recombination for SARS-CoV-2 at the population level, provide an update on the occurrence of newly circulating Omicron sublineages, and discuss the effectiveness of novel vaccines/therapeutic drugs against the Omicron variant.

Keywords: COVID-19, SARS-CoV-2, Omicron, recombinant, BA.5, vaccine

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APA
Wang, Y., Long, Y., Wang, F., Li, C., Liu, W. (2023). Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages. International Journal of Medical Sciences, 20(1), 151-162. https://doi.org/10.7150/ijms.79116.

ACS
Wang, Y.; Long, Y.; Wang, F.; Li, C.; Liu, W. Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages. Int. J. Med. Sci. 2023, 20 (1), 151-162. DOI: 10.7150/ijms.79116.

NLM
Wang Y, Long Y, Wang F, Li C, Liu W. Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages. Int J Med Sci 2023; 20(1):151-162. doi:10.7150/ijms.79116. https://www.medsci.org/v20p0151.htm

CSE
Wang Y, Long Y, Wang F, Li C, Liu W. 2023. Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages. Int J Med Sci. 20(1):151-162.

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