Int J Med Sci
2021; 18(3):639-645.
doi:10.7150/ijms.51150 This issueCite
Research Paper
Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage
1. Department of Pathology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. 2. Department of Neurology, Heyuan People's Hospital, Heyuan, 517000 China. 3. Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. 4. Institute of Neuroscience, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260 China. *These authors contributed equally to this work.
✉ Corresponding authors: Shiyin Xiao, Department of Neurosurgery and Neurosurgical Disease Research Centre, The Second Affiliated Hospital of Guangzhou Medical University. E-mail: xiaoshiyin81com, Tel.: +8618826434707; Yezhong Wang, M.D. The Second Affiliated Hospital of Guangzhou Medical University, People's Republic of China. E-mail: wangyezhongedu.cn, Tel.: +8613902237122.More
Citation:
Zhi C, Zeng S, Chen Y, Liao D, Lai M, Wang Z, Wang Y, Xiao S. Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage. Int J Med Sci 2021; 18(3):639-645. doi:10.7150/ijms.51150. https://www.medsci.org/v18p0639.htm
Intracerebral hemorrhage (ICH) represents a common acute cerebrovascular event that imparts high rates of disability. The microglia-mediated inflammatory response is a critical factor in determining cerebral damage post-ICH. Clemastine (CLM) is a histamine receptor H1 (HRH1) antagonist that has been shown to modulate the inflammatory response. However, the effects of CLM on ICH and the underlying mechanism remain to be determined. This investigation reveals that CLM resulted in reduction of cerebral hematoma volume, decreased cerebral edema and lower rates of neuronal apoptosis as well as improved behavioral scores in an acute ICH murine model. CLM treatment was noted to decrease pro-inflammatory effectors and increased anti-inflammatory effectors post-ICH. In addition, CLM reduced the deleterious effects of activated microglia on neurons in a transwell co-culture system. Our findings show that CLM likely mediates its therapeutic effect through inhibition of microglia-induced inflammatory response and apoptosis, thereby enhancing restoration of neuronal function.
Zhi, C., Zeng, S., Chen, Y., Liao, D., Lai, M., Wang, Z., Wang, Y., Xiao, S. (2021). Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage. International Journal of Medical Sciences, 18(3), 639-645. https://doi.org/10.7150/ijms.51150.
ACS
Zhi, C.; Zeng, S.; Chen, Y.; Liao, D.; Lai, M.; Wang, Z.; Wang, Y.; Xiao, S. Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage. Int. J. Med. Sci. 2021, 18 (3), 639-645. DOI: 10.7150/ijms.51150.
NLM
Zhi C, Zeng S, Chen Y, Liao D, Lai M, Wang Z, Wang Y, Xiao S. Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage. Int J Med Sci 2021; 18(3):639-645. doi:10.7150/ijms.51150. https://www.medsci.org/v18p0639.htm
CSE
Zhi C, Zeng S, Chen Y, Liao D, Lai M, Wang Z, Wang Y, Xiao S. 2021. Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage. Int J Med Sci. 18(3):639-645.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.