Int J Med Sci 2021; 18(2):347-355. doi:10.7150/ijms.50873

Research Paper

Clinical characteristics and follow-up analysis of 324 discharged COVID-19 patients in Shenzhen during the recovery period

Han-Qing Liu1#, Bo Yuan2#, Ya-Wen An1#, Kai-Jing Chen3, Qi Hu4, Xiao-Peng Hu1, Jia Zhao1, Yu Dong5, Yong-Xin Chen5, Wei-Xin Li5, Chang-Qing Sun6, Jian-Chun Wang1, Cheng Wang4✉, Shuo Song1✉

1. Central Laboratory, Shenzhen Samii Medical Center, Shenzhen 518118, China.
2. Department of Neurology, Shenzhen Samii Medical Center, Shenzhen 518118, China.
3. School of Biological Sciences, Nanyang Technological University, Singapore 637551.
4. Chinese Academy of Agricultural Sciences Agricultural Genomes Institute at Shenzhen, Genome Analysis Laboratory of the Ministry of Agriculture, Shenzhen 518118, China.
5. Department of Neurosurgery, Shenzhen Samii Medical Center, Shenzhen 518118, China.
6. Department of Clinical Laboratory, Shenzhen Samii Medical Center, Shenzhen 518118, China.
#These authors contributed equally to this work.

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Citation:
Liu HQ, Yuan B, An YW, Chen KJ, Hu Q, Hu XP, Zhao J, Dong Y, Chen YX, Li WX, Sun CQ, Wang JC, Wang C, Song S. Clinical characteristics and follow-up analysis of 324 discharged COVID-19 patients in Shenzhen during the recovery period. Int J Med Sci 2021; 18(2):347-355. doi:10.7150/ijms.50873. Available from https://www.medsci.org/v18p0347.htm

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Abstract

Objectives: Research on recovering COVID-19 patients could be helpful for containing the pandemic and developing vaccines, but we still do not know much about the clinical features, recovery process, and antibody reactions during the recovery period.

Methods: We retrospectively analysed the epidemiological information, discharge summaries, and laboratory results of 324 patients.

Results: In all, 15 (8.62%) patients experienced chest distress/breath shortness, where 8 of the 15 were severely ill. This means severely ill patients need an extended amount of time to recover after discharge; next, 20 (11.49%) patients experienced anxiety and 21 (12.07%) had headache/insomnia and a small fraction of them complained of anosmia/ageusia, indicating that these patients need treatment for mental and psychological health issues. Regarding the re-positive patients, their CT and laboratory test results showed no obvious evidence of illness progress or infectivity but a high anti-SARS-CoV-2 antibody expression.

Conclusion: Recovered COVID-19 patients need psychological and physiological care and treatment, re-positivity can occur in any person, but juveniles, females, and patients with mild/moderate existing symptoms have higher rates of re-positivity, While there is no evidence that turning re-positive has an impact on their infectivity, but it still alerted us that we need differentiate them in the following managements.

Keywords: Covid-19, vaccine, epidemiology, antibody