Int J Med Sci 2020; 17(18):2947-2953. doi:10.7150/ijms.49637 This issue

Research Paper

Ultrasound for Measuring the Cross-Sectional Area of Biceps Brachii Muscle in Sarcopenia

Shumin Li1, Hanyu Li1, Ying Hu2, Shaoming Zhu2, Zherong Xu1, Qin Zhang1,3, Yunmei Yang1,3✉, Zhaodi Wang1,3, Jia Xu3,4

1. Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China
2. Department of Ultrasound, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China
3. Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China
4. Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Li S, Li H, Hu Y, Zhu S, Xu Z, Zhang Q, Yang Y, Wang Z, Xu J. Ultrasound for Measuring the Cross-Sectional Area of Biceps Brachii Muscle in Sarcopenia. Int J Med Sci 2020; 17(18):2947-2953. doi:10.7150/ijms.49637. Available from https://www.medsci.org/v17p2947.htm

File import instruction

Abstract

Background: Ultrasound is emerging as an effective method for measuring muscle mass in elderly people. It has been applied in numerous studies to obtain measurement of lower limbs. The study aims to explore the relationship between sarcopenia and ultrasound measurements of biceps brachii.

Methods: Participants (n=179) aged over 60 years were enrolled from the first affiliated hospital of Zhejiang University. The muscle thickness (MT), cross-sectional area (CSA) and fat thickness (FT) of these participants were recorded. Spearman test and partial correlation test was used to determine the correlation between indicators. Mann-Whitney U test was performed to compare ultrasonic parameters between sarcopenia group and non-sarcopenia group. The binary logistic regression analysis was employed to detect the potential indicators and prediction equation of sarcopenia. Receiver operating characteristic (ROC) curve analysis was performed for the accuracy of equation.

Results: The prevalence of sarcopenia were 16.3% and 10.8% respectively in men and women. CSA was significantly lower in sarcopenia group than non-sarcopenia group in women (P<0.05). CSA was positively correlated with skeletal muscle mass index (SMI) and grip strength (men: r=0.460, 0.433; women: r=0.267, 0.392). After controlling of age and BMI, these correlations disappeared. Binary logistic regression analysis showed that age (OR=1.149, 95%CI: 1.060-1.246; P=0.001) and CSA (OR=0.465, 95%CI: 0.225-0.963; P=0.039) was significant indicators associated with sarcopenia. Area Under Curve was 0.822 (95%CI: 0.725-0.919, P<0.001) for the prediction equation composed of age, gender and CSA for sarcopenia.

Conclusion: CSA of the biceps brachii measured with ultrasound is an important indicator associated with sarcopenia.

Keywords: sarcopenia, ultrasound, biceps brachii, muscle mass