Int J Med Sci 2020; 17(16):2531-2543. doi:10.7150/ijms.46812

Research Paper

Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population

Haozhen Ma1,2, Jianmao Zheng1,2✉, Xiaolan Li1,2✉

1. Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, 510055 Guangzhou/PR. China.
2. Guanghua School of Stomatology, Sun Yat-sen University, 510055 Guangzhou/PR. China.

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Citation:
Ma H, Zheng J, Li X. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci 2020; 17(16):2531-2543. doi:10.7150/ijms.46812. Available from http://www.medsci.org/v17p2531.htm

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Abstract

Background: Some studies have reported biological linkages between periodontitis and esophageal cancer, prostate cancer, kidney cancer, hematological malignancy, and melanoma of the skin. This meta-analysis aimed to assess the relationship between periodontitis and the aforementioned five cancers.

Methods: Eligible studies on the association between periodontitis and the aforementioned five kinds of cancers were retrieved. The statistical analysis was conducted using Stata 12.0.

Results: Ten articles (more than 100,000 samples for most cancers) were included. With statistical significance, participants with periodontitis might have enhanced risks of esophageal cancer (HR = 1.79, 95% CI: 1.15-2.79), prostate cancer (HR = 1.20, 95% CI: 1.09-1.31), hematological malignancy (HR = 1.19, 95% CI: 1.09-1.29), and melanoma of skin (HR = 1.21, 95% CI: 1.03-1.42), compared with those without periodontitis. However, the evidence regarding the correlation between periodontitis and the susceptibility to kidney cancer was lacking (HR=1.30, 95% CI: 0.96-1.76).

Conclusions: The present meta-analysis revealed a potential link between periodontitis and esophageal cancer, prostate cancer, hematological malignancy, and melanoma of the skin. However, multi-center studies with large sample sizes and multivariable adjustments are still needed to support the conclusion.

Keywords: Esophageal cancer, prostate cancer, hematological malignancy, melanoma of the skin, periodontitis, meta-analysis