Int J Med Sci 2020; 17(10):1320-1326. doi:10.7150/ijms.45129

Review

The emerging role of EGFL6 in angiogenesis and tumor progression

Jing Kang1*, Juanjuan Wang1*, Jihua Tian1, Ruyi Shi2, Hongyan Jia3✉, Yanhong Wang1✉

1. Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi, China.
2. Department of Cell biology and Genetics, Shanxi Medical University, Taiyuan, Shanxi, China.
3. Department of General Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
*These authors contributed equally to this work.

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Citation:
Kang J, Wang J, Tian J, Shi R, Jia H, Wang Y. The emerging role of EGFL6 in angiogenesis and tumor progression. Int J Med Sci 2020; 17(10):1320-1326. doi:10.7150/ijms.45129. Available from http://www.medsci.org/v17p1320.htm

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Abstract

Epidermal growth factor-like domain-containing protein 6 (EGFL6) belongs to the epidermal growth factor (EGF) superfamily. EGFL6 is expressed at higher levels in embryos and various malignant tumors than in normal tissues. Recent studies suggest that EGFL6 participates in the development of a variety of tumors. In this review, we summarize findings that support the role for EGFL6 in tumor proliferation, invasion and migration. Furthermore, our review results indicate the mechanism of EGFL6 activity angiogenesis. We also describe work toward the preparation of monoclonal antibodies against EGFL6. Altogether, the work of this review promotes understanding of the role of EGFL6 in tumor development, the mechanism of that action, and the potential of EGFL6 as a therapeutic target for tumor prevention and treatment.

Keywords: EGFL, EGFL6, angiogenesis, tumorigenesis, biomarkers