Int J Med Sci 2020; 17(6):799-806. doi:10.7150/ijms.43832

Research Paper

Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma

Jun-Jie Zhou1, Yao Xiao1, Hao Li1, Cong-Cong Wu1, De-Run Chen1, Lei Chen1, Wei-Wei Deng1, Wen-Feng Zhang2✉, Zhi-Jun Sun1,2✉

1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China
2. Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, Hubei Province, China

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Citation:
Zhou JJ, Xiao Y, Li H, Wu CC, Chen DR, Chen L, Deng WW, Zhang WF, Sun ZJ. Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma. Int J Med Sci 2020; 17(6):799-806. doi:10.7150/ijms.43832. Available from http://www.medsci.org/v17p0799.htm

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Abstract

Our study investigated the expression of malic enzyme 2 (ME2) in human oral squamous cell carcinoma (OSCC) and associated pathological and clinical pattern. We demonstrated that human OSCC tissues expressed a high level of ME2, and the overexpression of ME2 is closely connected to a high pathological grade, lymphatic metastasis, large tumor size and human papillomavirus (HPV) (P < 0.001). Similarly, high levels of ME2 expression in OSCC tissue were shown to be correlated with poor prognosis (P < 0.05). The expression of ME2 was correlated with Slug, SOX2, and aldehyde dehydrogenase-1 (ALDH1) immunoreactivity.ME2 was shown to be overexpressed in OSCC tissue and indicated a poor prognosis for OSCC. ME2 may be correlated with several immune markers.

Keywords: malic enzyme 2, oral squamous cell carcinoma, ·prognosis, tissue microarrays