Int J Med Sci 2020; 17(4):490-497. doi:10.7150/ijms.40204

Research Paper

Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

Yi-Hung Sun1,2, Ying-Hsiang Chou1,3,4, Chu-Chyn Ou5,6, Soo-Cheen Ng7,8, Huang-Pin Shen1,7,8, Yueh‐Chun Lee1,4,7, Chun-Fang Hsu1, Shun-Fa Yang1,6, Po-Hui Wang1,6,7,8✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
2. Department of Obstetrics and Gynecology, Chi-Mei Foundation Medical Center, Tainan, Taiwan.
3. Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan.
4. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan.
5. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
6. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
7. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
8. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.

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Citation:
Sun YH, Chou YH, Ou CC, Ng SC, Shen HP, Lee Y, Hsu CF, Yang SF, Wang PH. Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women. Int J Med Sci 2020; 17(4):490-497. doi:10.7150/ijms.40204. Available from http://www.medsci.org/v17p0490.htm

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Abstract

The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 (MACC1) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 MACC1 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these MACC1 SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in MACC1 SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG (p=0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate (p=0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.

Keywords: metastasis-associated in colon cancer-1, single nucleotide polymorphisms, uterine cervical cancer, vaginal invasion, 5 years survival rate