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Int J Med Sci 2013; 10(13):1876-1879. doi:10.7150/ijms.6613 This issue Cite

Research Paper

Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation

Franjo Naji, Mihael Pagliaruzzi, Meta Penko, Vojko Kanic, Damijan Vokac✉

Department of Cardiology and Angiology, University Clinical Centre, Maribor, Slovenia.

✉ Corresponding author: Franjo Naji, MD, PhD. Department of Cardiology and Angiology, University Clinical Center Maribor, Ljubljanska 5, SI-2000 Maribor, Slovenia. Tel: 00386 2 321 2341 E-mail: franjo.najicom.

Citation:
Naji F, Pagliaruzzi M, Penko M, Kanic V, Vokac D. Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation. Int J Med Sci 2013; 10(13):1876-1879. doi:10.7150/ijms.6613. https://www.medsci.org/v10p1876.htm
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Abstract

BACKGROUND: Former studies showed possible interrelationship between altered ventricular filling patterns and atrial fibrillation (AF).

HYPOTHESIS: Long term persistent AF has a negative impact on left ventricular filling in patients with preserved ejection fraction of left ventricle.

METHODS: Our study was designed as a prospective case control study. We included 40 patients with persistent AF and preserved ejection fraction after successful electrical cardioversion and 43 control patients. Persistent AF was defined as AF lasting more than 4 weeks. Cardiac ultrasound was performed in all patients 24 hours after the procedure. Appropriate mitral flow and tissue Doppler velocities as well as standard echocardiographic measurements were obtained.

RESULTS: There were no significant differences between both groups' parameters regarding age, sex, commorbidities or drug therapy. Analysis of mitral flow velocities showed significant increase of E value in AF group (0.96±0.27 vs.0.70±0.14; p = 0.001). Tissue Doppler measurements didn't reveal any differences in early diastolic movement, however there was a statistically significant difference in E/Em values of both groups, respectively (12.0±4.0 vs. 9.0±2.1; p= 0.001).

CONCLUSION: Our study shows that in patients with preserved systolic function and persistent AF shortly after cardioversion diastolic ventricular filling patterns are altered mainly due to increased left atrial pressure and not due to impaired diastolic relaxation of left ventricle. Further studies are needed in order to define the interplay between diminished atrial function and impaired ventricular filling.

Keywords: atrial fibrillation, ventricular filling, diastolic relaxation, echocardiography, electrical cardioversion.

Citation styles

APA
Naji, F., Pagliaruzzi, M., Penko, M., Kanic, V., Vokac, D. (2013). Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation. International Journal of Medical Sciences, 10(13), 1876-1879. https://doi.org/10.7150/ijms.6613.

ACS
Naji, F.; Pagliaruzzi, M.; Penko, M.; Kanic, V.; Vokac, D. Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation. Int. J. Med. Sci. 2013, 10 (13), 1876-1879. DOI: 10.7150/ijms.6613.

NLM
Naji F, Pagliaruzzi M, Penko M, Kanic V, Vokac D. Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation. Int J Med Sci 2013; 10(13):1876-1879. doi:10.7150/ijms.6613. https://www.medsci.org/v10p1876.htm

CSE
Naji F, Pagliaruzzi M, Penko M, Kanic V, Vokac D. 2013. Changes in Left Ventricular Filling in Patients with Persistent Atrial Fibrillation. Int J Med Sci. 10(13):1876-1879.

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