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Int J Med Sci 2012; 9(4):311-315. doi:10.7150/ijms.4369 This issue Cite

Research Paper

Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia

Jun-Young Jung, Jin-Hee Han, Jae-Woo Yi, Jong-Man Kang✉

Department of Anesthesiology & Pain Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

✉ Corresponding author: Jong-Man Kang, M.D., Department of Anesthesiology & Pain Medicine, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong Gangdong-Gu, Seoul, Korea, Zip code: 134-090. Tel: 82-2-440-6193. Fax: 82-2-440-7808. E-mail: kjm More

Citation:
Jung JY, Han JH, Yi JW, Kang JM. Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia. Int J Med Sci 2012; 9(4):311-315. doi:10.7150/ijms.4369. https://www.medsci.org/v09p0311.htm
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Abstract

Aims: Prolonged tourniquet inflation produces a hyperdynamic cardiovascular response. We investigated the effect of continuous remifentanil infusion on systemic arterial pressure, heart rate, and cardiac output changes during prolonged tourniquet use in elderly patients under sevoflurane/N2O general anesthesia.

Methods: Thirty female patients scheduled for knee replacement arthroplasty were infused with either remifentanil at a target organ concentration of 2.0 ng/mL (remifentanil group, n = 15) or saline (control group, n = 15) after induction of anesthesia. Anesthesia was maintained with sevoflurane and N2O. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), cardiac index (CI), total systemic vascular resistance index (TSVRI), BIS, end-tidal sevoflurane concentration (EtSEVO), and end-tidal carbon dioxide concentration (EtCO2) were measured during the study period.

Results: There were significant differences in mean HR, SAP, DAP, and EtSEVO over time between the groups (P = 0.047, P < 0.001, P = 0.017, and P < 0.001, respectively). There was a statistically significant time trend effect (P < 0.001) in HR, SAP, DAP, and CI between the groups, with a statistically significant time-group interaction between the two groups (P = 0.02, 0.007, 0.001, 0.01, respectively).

Conclusion: The present study demonstrated that infusion with remifentanil prevented an increase in hemodynamic pressure during tourniquet inflation in elderly patients under sevoflurane/N2O general anesthesia.

Keywords: general anesthesia, knee replacement arthroplasty, remifentanil, tourniquet.

Citation styles

APA
Jung, J.Y., Han, J.H., Yi, J.W., Kang, J.M. (2012). Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia. International Journal of Medical Sciences, 9(4), 311-315. https://doi.org/10.7150/ijms.4369.

ACS
Jung, J.Y.; Han, J.H.; Yi, J.W.; Kang, J.M. Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia. Int. J. Med. Sci. 2012, 9 (4), 311-315. DOI: 10.7150/ijms.4369.

NLM
Jung JY, Han JH, Yi JW, Kang JM. Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia. Int J Med Sci 2012; 9(4):311-315. doi:10.7150/ijms.4369. https://www.medsci.org/v09p0311.htm

CSE
Jung JY, Han JH, Yi JW, Kang JM. 2012. Remifentanil Prevents Tourniquet-Induced Arterial Pressure Increase in Elderly Orthopedic Patients under Sevoflurane/N2O General Anesthesia. Int J Med Sci. 9(4):311-315.

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