Int J Med Sci 2019; 16(10):1366-1370. doi:10.7150/ijms.32795

Short Research Communication

Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus

Nan Nwe Win1#, Tatsuo Kanda2✉#, Masahiro Ogawa2#, Shingo Nakamoto1,3, Yuki Haga3, Reina Sasaki3, Masato Nakamura3, Shuang Wu3, Naoki Matsumoto2, Shunichi Matsuoka2, Naoya Kato3, Hiroshi Shirasawa1, Osamu Yokosuka3, Hiroaki Okamoto4, Mitsuhiko Moriyama2

1. Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan;
2. Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan; kanda.tatsuo@nihon-u.ac.jp (T.K.);
3. Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan;
4. Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
# These authors contributed equally.

Abstract

Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.

Keywords: HAV, HBV, dual infection, miso extracts, rice koji

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How to cite this article:
Win NN, Kanda T, Ogawa M, Nakamoto S, Haga Y, Sasaki R, Nakamura M, Wu S, Matsumoto N, Matsuoka S, Kato N, Shirasawa H, Yokosuka O, Okamoto H, Moriyama M. Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus. Int J Med Sci 2019; 16(10):1366-1370. doi:10.7150/ijms.32795. Available from http://www.medsci.org/v16p1366.htm