Int J Med Sci 2019; 16(10):1350-1355. doi:10.7150/ijms.33277 This issue Cite

Research Paper

Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model

Daniel Poehnert1✉*, Lavinia Neubert2*, Juergen Klempnauer1, Paul Borchert2, Danny Jonigk2, Markus Winny1

1. Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany
2. Institute of Pathology, Hannover Medical School, Hannover, Germany
* These authors contributed equally

Citation:
Poehnert D, Neubert L, Klempnauer J, Borchert P, Jonigk D, Winny M. Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model. Int J Med Sci 2019; 16(10):1350-1355. doi:10.7150/ijms.33277. https://www.medsci.org/v16p1350.htm
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Abstract

Adhesion barriers can be based on numerous substances. In the rat Optimized Peritoneal Adhesion Model (OPAM) the starch-based hemostats 4DryField and Arista were tested for their capability to act in a preventive manner against adhesion formation (applied as a powder that was mixed in situ with saline solution to form a barrier gel). Adhesions were scored using the established scoring systems by Lauder and Hoffmann, as well as histopathologically using the score by Zühlke. Animals receiving saline solution were used as controls. As previously published, 4DryField reduced peritoneal adhesions significantly. However, Arista did not lead to a statistically significant reduction of adhesion formation. When comparing 4DryField and Arista applied in the same manner, only 4DryField was significantly effective in preventing peritoneal adhesions. Histopathological evaluations confirmed the results of the macroscopic investigation, leading to the conclusion that starch-based hemostats do not generally have the capability to function as effective adhesion prevention devices.

Keywords: Adhesion prevention, abdominal surgery, rat model OPAM, 4DryField® PH, AristaTM AH


Citation styles

APA
Poehnert, D., Neubert, L., Klempnauer, J., Borchert, P., Jonigk, D., Winny, M. (2019). Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model. International Journal of Medical Sciences, 16(10), 1350-1355. https://doi.org/10.7150/ijms.33277.

ACS
Poehnert, D.; Neubert, L.; Klempnauer, J.; Borchert, P.; Jonigk, D.; Winny, M. Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model. Int. J. Med. Sci. 2019, 16 (10), 1350-1355. DOI: 10.7150/ijms.33277.

NLM
Poehnert D, Neubert L, Klempnauer J, Borchert P, Jonigk D, Winny M. Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model. Int J Med Sci 2019; 16(10):1350-1355. doi:10.7150/ijms.33277. https://www.medsci.org/v16p1350.htm

CSE
Poehnert D, Neubert L, Klempnauer J, Borchert P, Jonigk D, Winny M. 2019. Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model. Int J Med Sci. 16(10):1350-1355.

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