Int J Med Sci 2019; 16(6):902-908. doi:10.7150/ijms.34200

Review

NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases

Abhishek Suwal1*, Ji-long Hao1*, Xiu-fen Liu1*, Dan-dan Zhou2*, Om Prakash Pant1*, Ying Gao3*, Peng Hui1, Xin-xuan Dai1, Cheng-wei Lu1✉

1. Department of Ophthalmology, The First Hospital of Jilin University, No. 71 of Xinmin St., Changchun, Jilin Province, 130021, China.
2. Department of Radiology, The First Hospital of Jilin University, No. 71 of Xinmin St., Changchun, Jilin Province, 130021, China
3. Department of Endocrinology, The First Hospital of Jilin University, No. 71 of xinmin St., Changchun, Jilin Province, 130021, China
* These authors contributed equally to this work.

Abstract

Diabetes mellitus (DM) is a principal health problem with increasing incidence worldwide. It can be associated with various systemic diseases. Long non-coding RNA (lncRNA), a member of non-coding RNA has been newly linked with various human diseases. Recent evidence from animal experiments has shown that the incidence and development of type 2 diabetes are contributed by the atypical expression of lncRNA in which the biomarker with capable clinical potential was lncRNA NONRATT021972. In this review, we demonstrated the numerous functions of NONRATT021972 in different diabetes-related diseases including diabetic neuropathy, diabetic cardiac autonomic neuropathy, myocardial ischemia, and hepatic glucokinase dysfunction. The emerging evidence shows that the role of NONRATT021972 in diabetic-related disease is novel and therapeutic. These results direct us to conclude that NONRATT021972 is a potential diagnostic and future targeted therapy for diabetes-associated diseases.

Keywords: Diabetes mellitus, diabetes-related diseases, long non-coding RNA, NONRATT021972, myocardial ischemia, hepatic glucokinase

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How to cite this article:
Suwal A, Hao Jl, Liu Xf, Zhou Dd, Pant OP, Gao Y, Hui P, Dai Xx, Lu Cw. NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases. Int J Med Sci 2019; 16(6):902-908. doi:10.7150/ijms.34200. Available from http://www.medsci.org/v16p0902.htm