International Journal of Medical Sciences

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27 May 2019

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Int J Med Sci 2019; 16(5):704-710. doi:10.7150/ijms.32089

Review

Human Trabecular Meshwork Progenitors

Qin Zhu1, Yuan Zhang2, Sean Tighe2, Yongsong Liu3, Yingting Zhu2✉, Min Hu1✉

1. Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University (the Second People's Hospital of Yunnan Province); Yunnan Eye Institute; Key Laboratory of Yunnan Province for the Prevention and Treatment of ophthalmology (2017DG008); Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010); Expert Workstation of Yao Ke (2017IC064), Kunming 650021, China
2. Tissue Tech, Inc., Ocular Surface Center, and Ocular Surface Research & Education Foundation, Miami, FL, 33173 USA
3. Department of Ophthalmology, Yan' An Hospital of Kunming City, Kunming, 650051, China

Abstract

Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial dysfunction, and similar diseases. In order to promote the understanding of human trabecular meshwork progenitors, this article reviews human trabecular meshwork progenitor therapy and discusses its potential applications for curing human eye blindness.

Keywords: trabecular meshwork, progenitor, cell-based therapy, glaucoma

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhu Q, Zhang Y, Tighe S, Liu Y, Zhu Y, Hu M. Human Trabecular Meshwork Progenitors. Int J Med Sci 2019; 16(5):704-710. doi:10.7150/ijms.32089. Available from http://www.medsci.org/v16p0704.htm