Int J Med Sci 2019; 16(3):450-460. doi:10.7150/ijms.29935

Review

Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations

Mardiaty Iryani Abdullah1,5, Sarni Mat Junit1, Khoon Leong Ng2, Jaime Jacqueline Jayapalan3, Barani Karikalan4, Onn Haji Hashim1,3✉

1. Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
2. Department of Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
3. University of Malaya Centre for Proteomics Research, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
4. Perdana University, Jalan MAEPS Perdana, Serdang 43400, Selangor, Malaysia.
5. Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

Abstract

Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is usually contained within the thyroid gland and generally biologically indolent. Prognosis of the cancer is excellent, with less than 2% mortality at 5 years. However, more than 25% of patients with PTC developed a recurrence during a long term follow-up. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular alterations involved and recent biomarker investigations.

Keywords: papillary thyroid cancer, molecular alteration, genetic signature, biomarker, diagnostics

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How to cite this article:
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH. Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations. Int J Med Sci 2019; 16(3):450-460. doi:10.7150/ijms.29935. Available from http://www.medsci.org/v16p0450.htm