International Journal of Medical Sciences

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15 December 2018

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Int J Med Sci 2018; 15(14):1731-1736. doi:10.7150/ijms.27901

Research Paper

Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics

Sheng-Chun Hung1,2, Shian-Shiang Wang1,2,3, Jian-Ri Li1,2,4, Chuan-Shu Chen1,2, Chun-Kuang Yang2, Kun-Yuan Chiu2,3, Chen-Li Cheng1,2, Yen-Chuan Ou1,2,5, Hao-Chung Ho2, Shun-Fa Yang1,6✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan
3. Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan
4. Department of Medicine and Nursing, Hungkuang University, Taichung, Taiwan Taiwan
5. Department of Urology, Tung's Taichung MetroHarbor Hospital, Taichung, Taiwan
6. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Abstract

The high mobility group box 1 gene (HMGB1) plays a prominent role in cancer progression, angiogenesis, invasion, and metastasis. This study explored the effect of HMGB1 polymorphisms on clinicopathological characteristics of urothelial cell carcinoma (UCC). In total, 1293 participants (431 patients with UCC and 862 healthy controls) were recruited. Four single-nucleotide polymorphisms (SNPs) of HMGB1 (rs1412125, rs1360485, rs1045411, and rs2249825) were assessed using TaqMan real-time polymerase chain reaction assay. The results indicated that individuals carrying at least one T allele at rs1045411 had a lower risk of UCC than those with the wild-type allele [adjusted odds ratio = 0.722, 95% confidence interval (CI) = 0.565-0.924]. Furthermore, female patients with UCC carrying at least one T allele at rs1045411 were at a lower invasive tumor stage than those with the wild-type allele [odds ratio (OR) = 0.396, 95% CI = 0.169-0.929], similar to nonsmoking patients (OR = 0.607, 95% CI = 0.374-0.985). In conclusion, this is the first report on correlation between HMGB1 polymorphisms and UCC risk. Individuals carrying at least one T allele at rs1045411 are associated with a lower risk of UCC and a less invasive disease in women and nonsmokers.

Keywords: high mobility group box 1, polymorphism, urothelial cell carcinoma

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How to cite this article:
Hung SC, Wang SS, Li JR, Chen CS, Yang CK, Chiu KY, Cheng CL, Ou YC, Ho HC, Yang SF. Effect of HMGB1 Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathological Characteristics. Int J Med Sci 2018; 15(14):1731-1736. doi:10.7150/ijms.27901. Available from http://www.medsci.org/v15p1731.htm