International Journal of Medical Sciences

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23 October 2018

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Int J Med Sci 2018; 15(12):1334-1340. doi:10.7150/ijms.27059

Research Paper

Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics

Jr-Shiang Shiu1, Ming-Ju Hsieh2,3,4, Hui-Ling Chiou5,6, Hsiang-Ling Wang7, Chao-Bin Yeh8,9, Shun-Fa Yang2,10, Ying-Erh Chou8,10,✉

1. Department of Emergency Medicine, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan
2. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
3. Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan
4. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
5. School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
6. Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
7. Department of Beauty Science, National Taichung University of Science and Technology, Taichung, Taiwan
8. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
9. Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
10. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Abstract

A disintegrin and metalloprotease (ADAM) family proteins are type-I transmembrane glycoproteins with multiple functions in cell adhesion, migration, proteolysis and signaling. ADAM10 is a member of the ADAM family reportedly involved in cancer progression and has been shown to be overexpressed in hepatocellular carcinoma (HCC) tissues and significantly associated with tumor progression and shortened survival. This study investigated ADAM10's single nucleotide polymorphisms (SNPs) and their association to HCC development and regulation. Real-time polymerase chain reaction was used to analyze five SNPs of ADAM10 in 333 patients with HCC and 1196 controls without cancer. The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein. In conclusion, our study demonstrated that the SNPs of ADAM10 are involved in HCC progression. ADAM10 SNPs may be used as therapeutic targets to evaluate poor prognoses for HCC.

Keywords: Hepatocellular carcinoma, A disintegrin and metalloprotease 10, polymorphism

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How to cite this article:
Shiu JrS, Hsieh MJ, Chiou HL, Wang HL, Yeh CB, Yang SF, Chou YE. Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics. Int J Med Sci 2018; 15(12):1334-1340. doi:10.7150/ijms.27059. Available from http://www.medsci.org/v15p1334.htm