18 February 2019
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Int J Med Sci 2018; 15(11):1113-1117. doi:10.7150/ijms.25687
Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis
1. Department of Laboratory Medicine, University of Pécs Medical School, Pécs, Hungary
Background: Psoriasis is one of the most common chronic, life-long dermatologic diseases, which has considerable negative effects on quality of life. Psoriasis is considered as a systemic inflammatory disease, thus acute phase proteins such as C-reactive protein (CRP) and orosomucoid (ORM) have been shown to play a role in its pathophysiology. This study was aimed to compare CRP, serum ORM (se-ORM) and urinary ORM (u-ORM) levels of psoriatic patients to healthy individuals.
Methods: 87 psoriatic patients and 41 healthy individuals were enrolled. Simultaneously obtained venous blood and spot urine samples were analysed. High sensitivity CRP and se-ORM levels were determined by routine procedures on automated analyzers. Urinary ORM was measured by a novel automated turbidimetric assay. U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol).
Results: Significantly higher hsCRP (p<0.001) and u-ORM/u-CREAT (p=0.001) levels were found among psoriatic patients compared to controls. No significant differences were found between the groups regarding se-ORM levels. HsCRP, se-ORM and u-ORM/u-CREAT levels were significantly higher in patients with severe psoriasis than in mild and moderate cases (p<0.05).
Conclusion: As a highly sensitive, easily available biomarker u-ORM shows itself capable of becoming a new inflammatory marker in psoriasis providing clinically useful information on disease severity.
Keywords: Psoriasis, Orosomucoid, Urine, Biomarker, Inflammation
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How to cite this article:
Kustán P, Kőszegi T, Miseta A, Péter I, Ajtay Z, Kiss I, Németh B. Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis. Int J Med Sci 2018; 15(11):1113-1117. doi:10.7150/ijms.25687. Available from http://www.medsci.org/v15p1113.htm