International Journal of Medical Sciences

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24 September 2018

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Int J Med Sci 2018; 15(11):1113-1117. doi:10.7150/ijms.25687

Research Paper

Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis

Péter Kustán1,2, Tamás Kőszegi1,2, Attila Miseta1,2, Iván Péter3, Zénó Ajtay3, István Kiss4, Balázs Németh3,4,✉

1. Department of Laboratory Medicine, University of Pécs Medical School, Pécs, Hungary
2. János Szentágothai Research Centre, University of Pécs, Pécs, Hungary
3. Zsigmondy Vilmos SPA Hospital, Harkány, Hungary
4. Department of Public Health Medicine, University of Pécs Medical School, Pécs, Hungary

Abstract

Background: Psoriasis is one of the most common chronic, life-long dermatologic diseases, which has considerable negative effects on quality of life. Psoriasis is considered as a systemic inflammatory disease, thus acute phase proteins such as C-reactive protein (CRP) and orosomucoid (ORM) have been shown to play a role in its pathophysiology. This study was aimed to compare CRP, serum ORM (se-ORM) and urinary ORM (u-ORM) levels of psoriatic patients to healthy individuals.

Methods: 87 psoriatic patients and 41 healthy individuals were enrolled. Simultaneously obtained venous blood and spot urine samples were analysed. High sensitivity CRP and se-ORM levels were determined by routine procedures on automated analyzers. Urinary ORM was measured by a novel automated turbidimetric assay. U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol).

Results: Significantly higher hsCRP (p<0.001) and u-ORM/u-CREAT (p=0.001) levels were found among psoriatic patients compared to controls. No significant differences were found between the groups regarding se-ORM levels. HsCRP, se-ORM and u-ORM/u-CREAT levels were significantly higher in patients with severe psoriasis than in mild and moderate cases (p<0.05).

Conclusion: As a highly sensitive, easily available biomarker u-ORM shows itself capable of becoming a new inflammatory marker in psoriasis providing clinically useful information on disease severity.

Keywords: Psoriasis, Orosomucoid, Urine, Biomarker, Inflammation

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Kustán P, Kőszegi T, Miseta A, Péter I, Ajtay Z, Kiss I, Németh B. Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis. Int J Med Sci 2018; 15(11):1113-1117. doi:10.7150/ijms.25687. Available from http://www.medsci.org/v15p1113.htm