International Journal of Medical Sciences

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13 November 2018

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Int J Med Sci 2018; 15(9):921-928. doi:10.7150/ijms.26076

Research Paper

Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction

Samur Thanoi1,2✉, Jureepon Roboon1, Sutisa Nudmamud-Thanoi1,2

1. Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand
2. Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand

Abstract

Drug addiction is reported to have adverse effects in male reproduction. Dextromethorphan (DXM) administration was used in this study as a model of addiction in rats, and various treatments including the use of pre-germinated brown rice (PGBR) were investigated for their effects on the changes of sperm quality, testicular structure and androgen receptor (AR) expressions in rats receiving DXM. The results demonstrated that these animals showed significant reduction in all parameters of sperm quality, an increase in abnormal testicular structure and decreased androgen receptor expression in spermatogenic, Sertoli and Leydig cells. However, different effects of the treatments applied in this study were observed with the greatest recovery effect from treatment with PGBR. Sperm motility and sperm concentration reverted to normal after treatment with PGBR for 60 days. Moreover, all parameters of testicular structure also returned to normal after 60 days of PGBR treatment, as well as AR expression in Sertoli and Leydig cells. Therefore, we have demonstrated that PGBR treatment can reverse the changes in sperm quality, testicular structure and AR expression in addicted animals and PGBR may be a novel therapeutic strategy for the treatment of drug addiction.

Keywords: Drug addiction, Dextromethorphan, Sperm quality, Testicular structure, Androgen receptor

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How to cite this article:
Thanoi S, Roboon J, Nudmamud-Thanoi S. Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction. Int J Med Sci 2018; 15(9):921-928. doi:10.7150/ijms.26076. Available from http://www.medsci.org/v15p0921.htm